2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).

2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).

Abstract: Two-pore domain K+ (KCNK, K2P) channels underlie the leak (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability. These channels have been reported to be modulated by several physical and chemical stimuli. The compound...

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Main Authors: Leopoldo Raul Beltran, Madeline eBeltran, Ainhara eAguado, Guenter eGisselmann, Hanns eHatt
格式: 文件
语言:English
出版: Frontiers Media S.A. 2013-05-01
丛编:Frontiers in Pharmacology
主题:
2-APB
KCNK channels
TREK
Xenopus oocytes
two-electrode voltage clamp
在线阅读:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00063/full

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http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00063/full

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