Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome
Breaking down the endothelial barrier is a hallmark of systemic inflammatory response syndrome. Here the authors show that palmitoylation, a post-translational modification of proteins, plays a critical role in altering endothelial function during inflammation, and suggest the targeting of palmitoyl...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12823 |
| _version_ | 1819040283475574784 |
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| author | Richard S. Beard Xiaoyuan Yang Jamie E. Meegan Jonathan W. Overstreet Clement G.Y. Yang John A. Elliott Jason J. Reynolds Byeong J. Cha Christopher D. Pivetti David A. Mitchell Mack H. Wu Robert J. Deschenes Sarah Y. Yuan |
| author_facet | Richard S. Beard Xiaoyuan Yang Jamie E. Meegan Jonathan W. Overstreet Clement G.Y. Yang John A. Elliott Jason J. Reynolds Byeong J. Cha Christopher D. Pivetti David A. Mitchell Mack H. Wu Robert J. Deschenes Sarah Y. Yuan |
| author_sort | Richard S. Beard |
| collection | DOAJ |
| description | Breaking down the endothelial barrier is a hallmark of systemic inflammatory response syndrome. Here the authors show that palmitoylation, a post-translational modification of proteins, plays a critical role in altering endothelial function during inflammation, and suggest the targeting of palmitoyl acyltransferase DHHC21 as potential disease therapy. |
| first_indexed | 2024-12-21T09:06:38Z |
| format | Article |
| id | doaj.art-aa685ca2e0d54ba78aad1d96ea02b68e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:06:38Z |
| publishDate | 2016-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-aa685ca2e0d54ba78aad1d96ea02b68e2022-12-21T19:09:20ZengNature PortfolioNature Communications2041-17232016-09-017111910.1038/ncomms12823Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndromeRichard S. Beard0Xiaoyuan Yang1Jamie E. Meegan2Jonathan W. Overstreet3Clement G.Y. Yang4John A. Elliott5Jason J. Reynolds6Byeong J. Cha7Christopher D. Pivetti8David A. Mitchell9Mack H. Wu10Robert J. Deschenes11Sarah Y. Yuan12Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaDepartment of Surgery, Morsani College of Medicine, University of South FloridaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaDepartment of Surgery, School of Medicine, University of California at DavisDepartment of Molecular Medicine, Morsani College of Medicine, University of South FloridaDepartment of Surgery, Morsani College of Medicine, University of South FloridaDepartment of Molecular Medicine, Morsani College of Medicine, University of South FloridaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South FloridaBreaking down the endothelial barrier is a hallmark of systemic inflammatory response syndrome. Here the authors show that palmitoylation, a post-translational modification of proteins, plays a critical role in altering endothelial function during inflammation, and suggest the targeting of palmitoyl acyltransferase DHHC21 as potential disease therapy.https://doi.org/10.1038/ncomms12823 |
| spellingShingle | Richard S. Beard Xiaoyuan Yang Jamie E. Meegan Jonathan W. Overstreet Clement G.Y. Yang John A. Elliott Jason J. Reynolds Byeong J. Cha Christopher D. Pivetti David A. Mitchell Mack H. Wu Robert J. Deschenes Sarah Y. Yuan Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome Nature Communications |
| title | Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome |
| title_full | Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome |
| title_fullStr | Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome |
| title_full_unstemmed | Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome |
| title_short | Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome |
| title_sort | palmitoyl acyltransferase dhhc21 mediates endothelial dysfunction in systemic inflammatory response syndrome |
| url | https://doi.org/10.1038/ncomms12823 |
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