Hand transplantation: current challenges and future prospects
Noor Alolabi,1 Haley Augustine,1 Achilles Thoma1–3 1Division of Plastic Surgery, Department of Surgery, 2Surgical Outcomes Research Centre, 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Abstract: Over the last two decades, 113 vascularize...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-02-01
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| Series: | Transplant Research and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/hand-transplantation-current-challenges-and-future-prospects-peer-reviewed-article-TRRM |
| _version_ | 1818838317111705600 |
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| author | Alolabi N Augustine H Thoma A |
| author_facet | Alolabi N Augustine H Thoma A |
| author_sort | Alolabi N |
| collection | DOAJ |
| description | Noor Alolabi,1 Haley Augustine,1 Achilles Thoma1–3 1Division of Plastic Surgery, Department of Surgery, 2Surgical Outcomes Research Centre, 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Abstract: Over the last two decades, 113 vascularized composite allotransplantation (VCA) of the hand have been performed in 76 patients globally. The procedure that was once regarded as experimental has certainly emerged as a clinical reality with multiple centers worldwide now performing it. The psychological and physical impact of losing an upper extremity is profound. Amputees face significant challenges contributing to disability and dependence even with activities of daily living. Hand transplantation offers functions with restoring sensation, voluntary motor control, and proprioception, as well as a sense of feeling “whole” again. Along with these benefits, however, transplantation carries a significant risk profile attributed to the complications of life-long immunosuppression and possible rejection. Moreover, the procedure carries a significant financial burden to the health care system. As hand VCA is becoming more widely accepted and performed worldwide, there are still many challenges that will face its rapid growth. This review highlights some of the challenges facing hand VCA including patient selection, effect on quality of life, financial burden, functional outcomes, and complications of immunosuppression. Keywords: hand transplantation, vascularized composite allotransplantation |
| first_indexed | 2024-12-19T03:36:28Z |
| format | Article |
| id | doaj.art-aa688f753d4b470eb85d81816bc6fef8 |
| institution | Directory Open Access Journal |
| issn | 1179-1616 |
| language | English |
| last_indexed | 2024-12-19T03:36:28Z |
| publishDate | 2017-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Transplant Research and Risk Management |
| spelling | doaj.art-aa688f753d4b470eb85d81816bc6fef82022-12-21T20:37:22ZengDove Medical PressTransplant Research and Risk Management1179-16162017-02-01Volume 9232931464Hand transplantation: current challenges and future prospectsAlolabi NAugustine HThoma ANoor Alolabi,1 Haley Augustine,1 Achilles Thoma1–3 1Division of Plastic Surgery, Department of Surgery, 2Surgical Outcomes Research Centre, 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Abstract: Over the last two decades, 113 vascularized composite allotransplantation (VCA) of the hand have been performed in 76 patients globally. The procedure that was once regarded as experimental has certainly emerged as a clinical reality with multiple centers worldwide now performing it. The psychological and physical impact of losing an upper extremity is profound. Amputees face significant challenges contributing to disability and dependence even with activities of daily living. Hand transplantation offers functions with restoring sensation, voluntary motor control, and proprioception, as well as a sense of feeling “whole” again. Along with these benefits, however, transplantation carries a significant risk profile attributed to the complications of life-long immunosuppression and possible rejection. Moreover, the procedure carries a significant financial burden to the health care system. As hand VCA is becoming more widely accepted and performed worldwide, there are still many challenges that will face its rapid growth. This review highlights some of the challenges facing hand VCA including patient selection, effect on quality of life, financial burden, functional outcomes, and complications of immunosuppression. Keywords: hand transplantation, vascularized composite allotransplantationhttps://www.dovepress.com/hand-transplantation-current-challenges-and-future-prospects-peer-reviewed-article-TRRMHand transplantationvascularized composite allotransplantation |
| spellingShingle | Alolabi N Augustine H Thoma A Hand transplantation: current challenges and future prospects Transplant Research and Risk Management Hand transplantation vascularized composite allotransplantation |
| title | Hand transplantation: current challenges and future prospects |
| title_full | Hand transplantation: current challenges and future prospects |
| title_fullStr | Hand transplantation: current challenges and future prospects |
| title_full_unstemmed | Hand transplantation: current challenges and future prospects |
| title_short | Hand transplantation: current challenges and future prospects |
| title_sort | hand transplantation current challenges and future prospects |
| topic | Hand transplantation vascularized composite allotransplantation |
| url | https://www.dovepress.com/hand-transplantation-current-challenges-and-future-prospects-peer-reviewed-article-TRRM |
| work_keys_str_mv | AT alolabin handtransplantationcurrentchallengesandfutureprospects AT augustineh handtransplantationcurrentchallengesandfutureprospects AT thomaa handtransplantationcurrentchallengesandfutureprospects |