The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical Trial
Carnitine is necessary for allowing the long-chain fatty acids to pass the inner mitochondrial membrane to induce β -oxidation. Lack of carnitine and abnormalities of mitochondria play an important role in forming fatty deposition in the liver, and hence, developing steatohepatitis. Carnitine and ac...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences and Health Services
2023-05-01
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| Series: | Journal of Nutrition and Food Security |
| Subjects: | |
| Online Access: | http://jnfs.ssu.ac.ir/article-1-746-en.html |
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| author | Nasir Talenezhad Milad Akhlaghi Hamidreza Raeisi‐Dehkordi Sadegh Zarei Hassan Mozaffari-Khosravi |
| author_facet | Nasir Talenezhad Milad Akhlaghi Hamidreza Raeisi‐Dehkordi Sadegh Zarei Hassan Mozaffari-Khosravi |
| author_sort | Nasir Talenezhad |
| collection | DOAJ |
| description | Carnitine is necessary for allowing the long-chain fatty acids to pass the inner mitochondrial membrane to induce β -oxidation. Lack of carnitine and abnormalities of mitochondria play an important role in forming fatty deposition in the liver, and hence, developing steatohepatitis. Carnitine and acylcarnitine identified in human erythrocytes and intra-erythrocyte acetylcarnitine have a significant relationship with the plasma levels. Methods: The present study was conducted to investigate the possible effects of L-carnitine on liver function, folate and vitamin B12 levels in patients with type 2 diabetes mellitus (T2DM). In this study, 70 patients with T2DM were randomly assigned to either a L-carnitine (CG) and a placebo group (PG). For 12 weeks, the first group received 1000 mg/d oral L-carnitine, whereas the second group received 1000 mg/day wheat starch as placebo. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), folate, Vitamin B12, complete blood count (CBC) including blood cells and indicators related to anemia were assessed at baseline. Results: 64 patients managed to complete the study (32 in each group). The results indicated that consumption of L-carnitine compared with placebo had no significant effect on liver enzymes, folate, vitamin B12, and CBC with differential. Conclusions: Daily intake of 1000 mg L-carnitine for 12 weeks had no effect on liver function and anemia indicators including CBC, folate, and vitamins B12. |
| first_indexed | 2024-04-09T14:12:13Z |
| format | Article |
| id | doaj.art-aa6891fc78294597b5a4a7f25d99daa3 |
| institution | Directory Open Access Journal |
| issn | 2476-7417 2476-7425 |
| language | English |
| last_indexed | 2024-04-09T14:12:13Z |
| publishDate | 2023-05-01 |
| publisher | Shahid Sadoughi University of Medical Sciences and Health Services |
| record_format | Article |
| series | Journal of Nutrition and Food Security |
| spelling | doaj.art-aa6891fc78294597b5a4a7f25d99daa32023-05-06T06:48:59ZengShahid Sadoughi University of Medical Sciences and Health ServicesJournal of Nutrition and Food Security2476-74172476-74252023-05-0182283297The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical TrialNasir Talenezhad0Milad Akhlaghi1Hamidreza Raeisi‐Dehkordi2Sadegh Zarei3Hassan Mozaffari-Khosravi4 Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Clinical Biochemistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Department of Clinical Biochemistry,Rafsanjan University of Medical Sciences,Rafsanjan, Iran Carnitine is necessary for allowing the long-chain fatty acids to pass the inner mitochondrial membrane to induce β -oxidation. Lack of carnitine and abnormalities of mitochondria play an important role in forming fatty deposition in the liver, and hence, developing steatohepatitis. Carnitine and acylcarnitine identified in human erythrocytes and intra-erythrocyte acetylcarnitine have a significant relationship with the plasma levels. Methods: The present study was conducted to investigate the possible effects of L-carnitine on liver function, folate and vitamin B12 levels in patients with type 2 diabetes mellitus (T2DM). In this study, 70 patients with T2DM were randomly assigned to either a L-carnitine (CG) and a placebo group (PG). For 12 weeks, the first group received 1000 mg/d oral L-carnitine, whereas the second group received 1000 mg/day wheat starch as placebo. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), folate, Vitamin B12, complete blood count (CBC) including blood cells and indicators related to anemia were assessed at baseline. Results: 64 patients managed to complete the study (32 in each group). The results indicated that consumption of L-carnitine compared with placebo had no significant effect on liver enzymes, folate, vitamin B12, and CBC with differential. Conclusions: Daily intake of 1000 mg L-carnitine for 12 weeks had no effect on liver function and anemia indicators including CBC, folate, and vitamins B12.http://jnfs.ssu.ac.ir/article-1-746-en.htmlcarnitinediabetes mellituslivervitaminsclinical trial |
| spellingShingle | Nasir Talenezhad Milad Akhlaghi Hamidreza Raeisi‐Dehkordi Sadegh Zarei Hassan Mozaffari-Khosravi The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical Trial Journal of Nutrition and Food Security carnitine diabetes mellitus liver vitamins clinical trial |
| title | The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical Trial |
| title_full | The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical Trial |
| title_fullStr | The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical Trial |
| title_full_unstemmed | The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical Trial |
| title_short | The Effect of L-carnitine Supplementation on Liver Function, Folate and Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Clinical Trial |
| title_sort | effect of l carnitine supplementation on liver function folate and vitamin b12 levels in patients with type 2 diabetes mellitus a randomized double blind clinical trial |
| topic | carnitine diabetes mellitus liver vitamins clinical trial |
| url | http://jnfs.ssu.ac.ir/article-1-746-en.html |
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