Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome
Human brucellosis is one of the most prevalent zoonoses. There are many similarities between the pathogenesis of Mycobacterium tuberculosis (MTB) infection and that of brucellosis. Immune reconstitution inflammatory syndrome (IRIS) may occur during the treatment of MTB infection, but it has not been...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.923341/full |
| _version_ | 1828786275432267776 |
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| author | Chunmei Qu Nannan Xu Dehong Niu Sai Wen Hui Yang Shanshan Wang Gang Wang |
| author_facet | Chunmei Qu Nannan Xu Dehong Niu Sai Wen Hui Yang Shanshan Wang Gang Wang |
| author_sort | Chunmei Qu |
| collection | DOAJ |
| description | Human brucellosis is one of the most prevalent zoonoses. There are many similarities between the pathogenesis of Mycobacterium tuberculosis (MTB) infection and that of brucellosis. Immune reconstitution inflammatory syndrome (IRIS) may occur during the treatment of MTB infection, but it has not been reported in brucellosis cases thus far. We report the case of a 40-year-old male whose condition initially improved after adequate anti-Brucella therapy. However, 3 weeks later, the patient presented with exacerbation of symptoms and development of a paravertebral abscess. After exclusion of other possible causes of clinical deterioration, immune reconstitution inflammatory syndrome (IRIS) with brucellosis was presumed. After supplementation with anti-Brucella treatment with corticosteroids, the abscess disappeared, and the symptoms completely resolved. Our case suggests that it is necessary to be aware of the possible occurrence of IRIS in patients with brucellosis in clinical practice. |
| first_indexed | 2024-12-12T00:07:26Z |
| format | Article |
| id | doaj.art-aa6a2f3a414743eba3bed1e4b249183c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T00:07:26Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-aa6a2f3a414743eba3bed1e4b249183c2022-12-22T00:45:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.923341923341Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory SyndromeChunmei Qu0Nannan Xu1Dehong Niu2Sai Wen3Hui Yang4Shanshan Wang5Gang Wang6Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Oncology, the Fifth People’s Hospital of Jinan, Jinan, ChinaDepartment of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaHuman brucellosis is one of the most prevalent zoonoses. There are many similarities between the pathogenesis of Mycobacterium tuberculosis (MTB) infection and that of brucellosis. Immune reconstitution inflammatory syndrome (IRIS) may occur during the treatment of MTB infection, but it has not been reported in brucellosis cases thus far. We report the case of a 40-year-old male whose condition initially improved after adequate anti-Brucella therapy. However, 3 weeks later, the patient presented with exacerbation of symptoms and development of a paravertebral abscess. After exclusion of other possible causes of clinical deterioration, immune reconstitution inflammatory syndrome (IRIS) with brucellosis was presumed. After supplementation with anti-Brucella treatment with corticosteroids, the abscess disappeared, and the symptoms completely resolved. Our case suggests that it is necessary to be aware of the possible occurrence of IRIS in patients with brucellosis in clinical practice.https://www.frontiersin.org/articles/10.3389/fimmu.2022.923341/fullhuman brucellosisIRISimmune reconstitutioninfectioncase report |
| spellingShingle | Chunmei Qu Nannan Xu Dehong Niu Sai Wen Hui Yang Shanshan Wang Gang Wang Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome Frontiers in Immunology human brucellosis IRIS immune reconstitution infection case report |
| title | Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome |
| title_full | Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome |
| title_fullStr | Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome |
| title_full_unstemmed | Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome |
| title_short | Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome |
| title_sort | case report suspected case of brucella associated immune reconstitution inflammatory syndrome |
| topic | human brucellosis IRIS immune reconstitution infection case report |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.923341/full |
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