Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI
ObjectivePrevious studies have discussed the impact of chemotherapy on the brain microstructure. There is no evidence of the impact regarding cancer-related psychiatric comorbidity on cancer survivors. We aimed to evaluate the impact of both chemotherapy and mental health problem on brain microstruc...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1161246/full |
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| author | Vincent Chin-Hung Chen Vincent Chin-Hung Chen Wei Chuang Chien-Wei Chen Chien-Wei Chen Yuan-Hsiung Tsai Yuan-Hsiung Tsai Roger S. McIntyre Roger S. McIntyre Roger S. McIntyre Jun-Cheng Weng Jun-Cheng Weng Jun-Cheng Weng |
| author_facet | Vincent Chin-Hung Chen Vincent Chin-Hung Chen Wei Chuang Chien-Wei Chen Chien-Wei Chen Yuan-Hsiung Tsai Yuan-Hsiung Tsai Roger S. McIntyre Roger S. McIntyre Roger S. McIntyre Jun-Cheng Weng Jun-Cheng Weng Jun-Cheng Weng |
| author_sort | Vincent Chin-Hung Chen |
| collection | DOAJ |
| description | ObjectivePrevious studies have discussed the impact of chemotherapy on the brain microstructure. There is no evidence of the impact regarding cancer-related psychiatric comorbidity on cancer survivors. We aimed to evaluate the impact of both chemotherapy and mental health problem on brain microstructural alterations and consequent cognitive dysfunction in breast cancer survivors.MethodsIn this cross-sectional study conducted in a tertiary center, data from 125 female breast cancer survivors who had not received chemotherapy (BB = 65; 49.86 ± 8.23 years) and had received chemotherapy (BA = 60; 49.82 ± 7.89 years) as well as from 71 age-matched healthy controls (47.18 ± 8.08 years) was collected. Chemotherapeutic agents used were docetaxel and epirubicin. We used neuropsychological testing and questionnaire to evaluate psychiatric comorbidity, cognitive dysfunction as well as generalized sampling imaging (GQI) and graph theoretical analysis (GTA) to detect microstructural alterations in the brain.FindingsCross-comparison between groups revealed that neurotoxicity caused by chemotherapy and cancer-related psychiatric comorbidity may affect the corpus callosum and middle frontal gyrus. In addition, GQI indices were correlated with the testing scores of cognitive function, quality of life, anxiety, and depression. Furthermore, weaker connections between brain regions and lower segregated ability were found in the post-treatment group.ConclusionThis study suggests that chemotherapy and cancer-related mental health problem both play an important role in the development of white matter alterations and cognitive dysfunction. |
| first_indexed | 2024-03-13T06:36:17Z |
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| id | doaj.art-aa6a7057b9384a72a356ea3a9904a6f4 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-13T06:36:17Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-aa6a7057b9384a72a356ea3a9904a6f42023-06-09T04:33:11ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-06-011410.3389/fpsyt.2023.11612461161246Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRIVincent Chin-Hung Chen0Vincent Chin-Hung Chen1Wei Chuang2Chien-Wei Chen3Chien-Wei Chen4Yuan-Hsiung Tsai5Yuan-Hsiung Tsai6Roger S. McIntyre7Roger S. McIntyre8Roger S. McIntyre9Jun-Cheng Weng10Jun-Cheng Weng11Jun-Cheng Weng12School of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Psychiatry, Chang Gung Memorial Hospital, Chiayi, TaiwanDepartment of Medical Imaging and Radiological Sciences, Department of Artificial Intelligence, Chang Gung University, Taoyuan, TaiwanSchool of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, TaiwanSchool of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, TaiwanMood Disorder Psychopharmacology Unit, Department of Psychiatry, University Health Network, University of Toronto, Toronto, ON, CanadaInstitute of Medical Science, University of Toronto, Toronto, ON, CanadaDepartments of Psychiatry and Pharmacology, University of Toronto, Toronto, ON, CanadaDepartment of Psychiatry, Chang Gung Memorial Hospital, Chiayi, TaiwanDepartment of Medical Imaging and Radiological Sciences, Department of Artificial Intelligence, Chang Gung University, Taoyuan, TaiwanMedical Imaging Research Center, Institute for Radiological Research, Chang Gung University, Taoyuan, TaiwanObjectivePrevious studies have discussed the impact of chemotherapy on the brain microstructure. There is no evidence of the impact regarding cancer-related psychiatric comorbidity on cancer survivors. We aimed to evaluate the impact of both chemotherapy and mental health problem on brain microstructural alterations and consequent cognitive dysfunction in breast cancer survivors.MethodsIn this cross-sectional study conducted in a tertiary center, data from 125 female breast cancer survivors who had not received chemotherapy (BB = 65; 49.86 ± 8.23 years) and had received chemotherapy (BA = 60; 49.82 ± 7.89 years) as well as from 71 age-matched healthy controls (47.18 ± 8.08 years) was collected. Chemotherapeutic agents used were docetaxel and epirubicin. We used neuropsychological testing and questionnaire to evaluate psychiatric comorbidity, cognitive dysfunction as well as generalized sampling imaging (GQI) and graph theoretical analysis (GTA) to detect microstructural alterations in the brain.FindingsCross-comparison between groups revealed that neurotoxicity caused by chemotherapy and cancer-related psychiatric comorbidity may affect the corpus callosum and middle frontal gyrus. In addition, GQI indices were correlated with the testing scores of cognitive function, quality of life, anxiety, and depression. Furthermore, weaker connections between brain regions and lower segregated ability were found in the post-treatment group.ConclusionThis study suggests that chemotherapy and cancer-related mental health problem both play an important role in the development of white matter alterations and cognitive dysfunction.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1161246/fullbreast cancerchemotherapypsychiatric comorbiditygeneralized q-sampling imaginggraph theoretical analysis |
| spellingShingle | Vincent Chin-Hung Chen Vincent Chin-Hung Chen Wei Chuang Chien-Wei Chen Chien-Wei Chen Yuan-Hsiung Tsai Yuan-Hsiung Tsai Roger S. McIntyre Roger S. McIntyre Roger S. McIntyre Jun-Cheng Weng Jun-Cheng Weng Jun-Cheng Weng Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI Frontiers in Psychiatry breast cancer chemotherapy psychiatric comorbidity generalized q-sampling imaging graph theoretical analysis |
| title | Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI |
| title_full | Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI |
| title_fullStr | Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI |
| title_full_unstemmed | Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI |
| title_short | Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI |
| title_sort | detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q sampling mri |
| topic | breast cancer chemotherapy psychiatric comorbidity generalized q-sampling imaging graph theoretical analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1161246/full |
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