| Summary: | In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [<sup>99m</sup>TcN]<sup>2+</sup> core to obtain the <sup>99m</sup>TcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that <sup>99m</sup>TcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that <sup>99m</sup>TcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to <sup>99m</sup>TcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of <sup>99m</sup>TcN-CPF2XT were higher and the uptakes of <sup>99m</sup>TcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that <sup>99m</sup>TcN-CPF2XT would be a potential bacterial infection imaging agent.
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