Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2

Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2

Abstract Chromobox protein homolog 2 (CBX2) exerts a multifaceted impact on the progression of aggressive cancers. The proteasome-dependent pathway is crucial for modulating CBX2 regulation, while the specific regulatory roles and mechanisms of deubiquitinating enzymes targeting CBX2 remain poorly u...

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Bibliographic Details
Main Authors: Yushu Xing, Jirimu Ba-tu, Chongyang Dong, Xiaodong Cao, Bing Li, Xin Jia, Yu Juan, Xiaojie Lv, Huiwen Zhang, Na Qin, Wuri Han, Dongfeng Wang, Xiao Qi, Yutong Wang, Xulu Hao, Shuang Zhang, Xiaoli Du, Huanyun Wang, Minjie Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06304-y

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