SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20796-8 |
| _version_ | 1818749670939164672 |
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| author | Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis |
| author_facet | Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis |
| author_sort | Alyssa E. Johnson |
| collection | DOAJ |
| description | Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan. |
| first_indexed | 2024-12-18T04:07:29Z |
| format | Article |
| id | doaj.art-aa6baecf1a634bae8c342d74ef2c74a7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:07:29Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-aa6baecf1a634bae8c342d74ef2c74a72022-12-21T21:21:34ZengNature PortfolioNature Communications2041-17232021-01-0112111710.1038/s41467-020-20796-8SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespanAlyssa E. Johnson0Brian O. Orr1Richard D. Fetter2Armen J. Moughamian3Logan A. Primeaux4Ethan G. Geier5Jennifer S. Yokoyama6Bruce L. Miller7Graeme W. Davis8Department of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San FranciscoDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San FranciscoDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San FranciscoDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San FranciscoDepartment of Biological Sciences, Louisiana State UniversityDepartment of Biological Sciences, Louisiana State UniversityDepartment of Neurology, Memory and Aging Center, University of California, San FranciscoDepartment of Neurology, Memory and Aging Center, University of California, San FranciscoDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San FranciscoValosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.https://doi.org/10.1038/s41467-020-20796-8 |
| spellingShingle | Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan Nature Communications |
| title | SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan |
| title_full | SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan |
| title_fullStr | SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan |
| title_full_unstemmed | SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan |
| title_short | SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan |
| title_sort | svip is a molecular determinant of lysosomal dynamic stability neurodegeneration and lifespan |
| url | https://doi.org/10.1038/s41467-020-20796-8 |
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