Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer
Lung cancer still is one of the most common malignancy tumors in the world. However, the mechanisms of its occurrence and development have not been fully elucidated. Zinc finger protein family (ZNFs) is the largest transcription factor family in human genome. Recently, the more and more basic and cl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024043238 |
| _version_ | 1827308904908849152 |
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| author | Yang Shi Min Yao Shuijie Shen Li Wang Dengfu Yao |
| author_facet | Yang Shi Min Yao Shuijie Shen Li Wang Dengfu Yao |
| author_sort | Yang Shi |
| collection | DOAJ |
| description | Lung cancer still is one of the most common malignancy tumors in the world. However, the mechanisms of its occurrence and development have not been fully elucidated. Zinc finger protein family (ZNFs) is the largest transcription factor family in human genome. Recently, the more and more basic and clinical evidences have confirmed that ZNFs/Krüppel-like factors (KLFs) refer to a group of conserved zinc finger-containing transcription factors that are involved in lung cancer progression, with the functions of promotion, inhibition, dual roles and unknown classifications. Based on the recent literature, some of the oncogenic KLFs are promising molecular biomarkers for diagnosis, prognosis or therapeutic targets of lung cancer. Interestingly, a novel computational approach has been proposed by using machine learning on features calculated from primary sequences, the XGBoost-based model with accuracy of 96.4 % is efficient in identifying KLF proteins. This paper reviews the recent some progresses of the oncogenic KLFs with their potential values for diagnosis, prognosis and molecular target in lung cancer. |
| first_indexed | 2024-04-24T19:19:56Z |
| format | Article |
| id | doaj.art-aa6cf20031c34d6eb83d661d4295ab75 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T19:19:56Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-aa6cf20031c34d6eb83d661d4295ab752024-03-26T04:26:51ZengElsevierHeliyon2405-84402024-04-01107e28292Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancerYang Shi0Min Yao1Shuijie Shen2Li Wang3Dengfu Yao4Research Center of Clinical Medicine, Affiliated Hospital of Nantong University & Department of Medical Immunology, Medical School of Nantong University, Nantong 226001, China; Department of Thoracic Surgery, First People's Hospital of Yancheng, Yancheng 224001, ChinaResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University & Department of Medical Immunology, Medical School of Nantong University, Nantong 226001, ChinaResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University & Department of Medical Immunology, Medical School of Nantong University, Nantong 226001, ChinaResearch Center for Intelligent Information Technology, Nantong University, Nantong 226019, Jiangsu, China; Corresponding author.Research Center of Clinical Medicine, Affiliated Hospital of Nantong University & Department of Medical Immunology, Medical School of Nantong University, Nantong 226001, China; Corresponding author. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong 226001, Jiangsu, China.Lung cancer still is one of the most common malignancy tumors in the world. However, the mechanisms of its occurrence and development have not been fully elucidated. Zinc finger protein family (ZNFs) is the largest transcription factor family in human genome. Recently, the more and more basic and clinical evidences have confirmed that ZNFs/Krüppel-like factors (KLFs) refer to a group of conserved zinc finger-containing transcription factors that are involved in lung cancer progression, with the functions of promotion, inhibition, dual roles and unknown classifications. Based on the recent literature, some of the oncogenic KLFs are promising molecular biomarkers for diagnosis, prognosis or therapeutic targets of lung cancer. Interestingly, a novel computational approach has been proposed by using machine learning on features calculated from primary sequences, the XGBoost-based model with accuracy of 96.4 % is efficient in identifying KLF proteins. This paper reviews the recent some progresses of the oncogenic KLFs with their potential values for diagnosis, prognosis and molecular target in lung cancer.http://www.sciencedirect.com/science/article/pii/S2405844024043238Lung cancerKrüppel-like factorsZinc finger proteinsRegulatory mechanismTumor biomarkersTargeted therapy |
| spellingShingle | Yang Shi Min Yao Shuijie Shen Li Wang Dengfu Yao Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer Heliyon Lung cancer Krüppel-like factors Zinc finger proteins Regulatory mechanism Tumor biomarkers Targeted therapy |
| title | Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer |
| title_full | Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer |
| title_fullStr | Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer |
| title_full_unstemmed | Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer |
| title_short | Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer |
| title_sort | abnormal expression of kruppel like transcription factors and their potential values in lung cancer |
| topic | Lung cancer Krüppel-like factors Zinc finger proteins Regulatory mechanism Tumor biomarkers Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024043238 |
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