Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation
Visual neuroadaptation is believed to play an important role in determining the final visual outcomes following intraocular lens (IOL) implantation. To investigate visual neuroadaptation in patients with age-related cataracts (ARCs) after phacoemulsification with multifocal and monofocal IOL implant...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-06-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.648863/full |
| _version_ | 1818898260967817216 |
|---|---|
| author | Li Zhang Li Zhang Li Zhang Duoru Lin Yong Wang Wan Chen Wei Xiao Yi Xiang Yi Zhu Chuan Chen Xiying Dong Yizhi Liu Weirong Chen Haotian Lin |
| author_facet | Li Zhang Li Zhang Li Zhang Duoru Lin Yong Wang Wan Chen Wei Xiao Yi Xiang Yi Zhu Chuan Chen Xiying Dong Yizhi Liu Weirong Chen Haotian Lin |
| author_sort | Li Zhang |
| collection | DOAJ |
| description | Visual neuroadaptation is believed to play an important role in determining the final visual outcomes following intraocular lens (IOL) implantation. To investigate visual neuroadaptation in patients with age-related cataracts (ARCs) after phacoemulsification with multifocal and monofocal IOL implantation, we conducted a prospective, controlled clinical trial in Zhongshan Ophthalmology Center. This study included 22 patients with bilateral ARCs: 11 patients underwent phacoemulsification and multifocal IOL (Mu-IOL) implantation, and 11 patients underwent phacoemulsification and monofocal IOL (Mo-IOL) implantation. Visual disturbances (glare and halos), visual function (including visual acuity, retinal straylight, contrast sensitivity, and visual evoked potentials) and visual cortical function (fractional amplitude of low-frequency fluctuations, fALFF) in Bowman’s areas 17–19 as the region of interest were assessed before and after surgeries. The results showed that the fALFF values of the visual cortex in the Mu-IOL group decreased at 1 week postoperatively and recovered to baseline at 3 months and then improved at 6 months, compared with preoperative levels (at a whole-brain threshold of P < 0.05, AlphaSim-corrected, voxels > 228, repeated measures analysis of variance). Significantly increased fALFF values in the visual cortex were detected 1 week after surgery in the Mo-IOL group and decreased to baseline at 3 and 6 months. The fALFF of the lingual gyrus was negatively correlated with visual disturbances (P < 0.05). To conclude, early postoperative visual neuroadaptation was detected in the Mu-IOL group by resting-state fMRI analysis. The different changing trends of postoperative fALFF values in the two groups indicated distinct neuroadaptations patterns after Mu-IOL and Mo-IOL implantation. |
| first_indexed | 2024-12-19T19:29:15Z |
| format | Article |
| id | doaj.art-aa6fbd103532457b8d44d1d23538401b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T19:29:15Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-aa6fbd103532457b8d44d1d23538401b2022-12-21T20:08:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-06-011510.3389/fnins.2021.648863648863Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens ImplantationLi Zhang0Li Zhang1Li Zhang2Duoru Lin3Yong Wang4Wan Chen5Wei Xiao6Yi Xiang7Yi Zhu8Chuan Chen9Xiying Dong10Yizhi Liu11Weirong Chen12Haotian Lin13State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Aier Eye Hospital, Aier Eye Hospital of Wuhan University, Wuhan, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaWuhan Aier Eye Hospital, Aier Eye Hospital of Wuhan University, Wuhan, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, United StatesSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United StatesChinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaVisual neuroadaptation is believed to play an important role in determining the final visual outcomes following intraocular lens (IOL) implantation. To investigate visual neuroadaptation in patients with age-related cataracts (ARCs) after phacoemulsification with multifocal and monofocal IOL implantation, we conducted a prospective, controlled clinical trial in Zhongshan Ophthalmology Center. This study included 22 patients with bilateral ARCs: 11 patients underwent phacoemulsification and multifocal IOL (Mu-IOL) implantation, and 11 patients underwent phacoemulsification and monofocal IOL (Mo-IOL) implantation. Visual disturbances (glare and halos), visual function (including visual acuity, retinal straylight, contrast sensitivity, and visual evoked potentials) and visual cortical function (fractional amplitude of low-frequency fluctuations, fALFF) in Bowman’s areas 17–19 as the region of interest were assessed before and after surgeries. The results showed that the fALFF values of the visual cortex in the Mu-IOL group decreased at 1 week postoperatively and recovered to baseline at 3 months and then improved at 6 months, compared with preoperative levels (at a whole-brain threshold of P < 0.05, AlphaSim-corrected, voxels > 228, repeated measures analysis of variance). Significantly increased fALFF values in the visual cortex were detected 1 week after surgery in the Mo-IOL group and decreased to baseline at 3 and 6 months. The fALFF of the lingual gyrus was negatively correlated with visual disturbances (P < 0.05). To conclude, early postoperative visual neuroadaptation was detected in the Mu-IOL group by resting-state fMRI analysis. The different changing trends of postoperative fALFF values in the two groups indicated distinct neuroadaptations patterns after Mu-IOL and Mo-IOL implantation.https://www.frontiersin.org/articles/10.3389/fnins.2021.648863/fullvisual disturbancesvisual functionvisual neuroadaptationfunctional magnetic resonance imagingmultifocal intraocular lensmonofocal intraocular lens |
| spellingShingle | Li Zhang Li Zhang Li Zhang Duoru Lin Yong Wang Wan Chen Wei Xiao Yi Xiang Yi Zhu Chuan Chen Xiying Dong Yizhi Liu Weirong Chen Haotian Lin Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation Frontiers in Neuroscience visual disturbances visual function visual neuroadaptation functional magnetic resonance imaging multifocal intraocular lens monofocal intraocular lens |
| title | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
| title_full | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
| title_fullStr | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
| title_full_unstemmed | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
| title_short | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
| title_sort | comparison of visual neuroadaptations after multifocal and monofocal intraocular lens implantation |
| topic | visual disturbances visual function visual neuroadaptation functional magnetic resonance imaging multifocal intraocular lens monofocal intraocular lens |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.648863/full |
| work_keys_str_mv | AT lizhang comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT lizhang comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT lizhang comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT duorulin comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT yongwang comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT wanchen comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT weixiao comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT yixiang comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT yizhu comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT chuanchen comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT xiyingdong comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT yizhiliu comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT weirongchen comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation AT haotianlin comparisonofvisualneuroadaptationsaftermultifocalandmonofocalintraocularlensimplantation |