Method development for quantification of DMET-proteins in the paediatric intestinal tract via LC-MS/MS using a QconCAT technique

Method development for quantification of DMET-proteins in the paediatric intestinal tract via LC-MS/MS using a QconCAT technique

Physiologically based pharmacokinetic (PBPK) modelling is a powerful alternative for paediatric clinical trials. Paediatric PBPK models require data on intestinal drug metabolising enzymes and transporter (DMET)-protein abundances, however only limited data is available. This is the first study to r...

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Bibliographic Details
Main Authors: Jan Goelen, Richard D Horniblow, Hannah Batchelor
Format: Article
Language:English
Published: University of Huddersfield Press 2022-11-01
Series:British Journal of Pharmacy
Subjects:
paediatrics
proteomics
pbpk modelling
biopharmaceutics
Online Access:https://www.bjpharm.org.uk/article/id/1166/

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