BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018
Abstract Background Studies have examined the effect of weight change on osteoporosis, but the results were controversial. Among them, few had looked at weight change over the life span. This study aimed to fill this gap and investigate the association between lifetime body mass index (BMI) trajecto...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-023-04397-9 |
| _version_ | 1797556801022984192 |
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| author | Jiacheng Wang Yi Zheng Yawen Wang Chengjun Zhang Yanfeng Jiang Chen Suo Mei Cui Tiejun Zhang Xingdong Chen Kelin Xu |
| author_facet | Jiacheng Wang Yi Zheng Yawen Wang Chengjun Zhang Yanfeng Jiang Chen Suo Mei Cui Tiejun Zhang Xingdong Chen Kelin Xu |
| author_sort | Jiacheng Wang |
| collection | DOAJ |
| description | Abstract Background Studies have examined the effect of weight change on osteoporosis, but the results were controversial. Among them, few had looked at weight change over the life span. This study aimed to fill this gap and investigate the association between lifetime body mass index (BMI) trajectories and bone loss. Methods In this cross-sectional study, participants at age 50 and above were selected from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Dual-energy X-ray Absorptiometry was used to measure the bone mineral density at the femoral neck and lumbar spine. Standard BMI criteria were used, with < 25 kg/m2 for normal, 25–29.9 kg/m2 for overweight, and ≥ 30 kg/m2 for obesity. The latent class trajectory model (LCTM) was used to identify BMI trajectories. Multinomial logistic regression models were fitted to evaluate the association between different BMI trajectories and osteoporosis or osteopenia. Results For the 9,706 eligible participants, we identified four BMI trajectories, including stable (n = 7,681, 70.14%), slight increase (n = 1253, 12.91%), increase to decrease (n = 195, 2.01%), and rapid increase (n = 577, 5.94%). Compared with individuals in the stable trajectory, individuals in the rapid increase trajectory had higher odds of osteoporosis (OR = 2.25, 95% CI 1.19–4.23) and osteopenia (OR = 1.49, 95% CI 1.02–2.17). This association was only found in the lumbar spine (OR = 2.11, 95% CI 1.06–4.2) but not in the femoral neck. In early-stage (age 25–10 years ago) weight change, staying an obesity and stable weight seemed to have protective effects on osteoporosis (OR = 0.26, 95% CI 0.08–0.77) and osteopenia (OR = 0.46, 95% CI 0.25–0.84). Meanwhile, keeping an early-stage stable and overweight was related to lower odds of osteopenia (OR = 0.53, 95% CI 0.34–0.83). No statistically significant association between recent (10 years ago to baseline) weight change and osteoporosis was found. Conclusions Rapid and excess weight gain during adulthood is associated with a higher risk of osteoporosis. But this association varies by skeletal sites. Maintaining stable overweight and obesity at an early stage may have potentially beneficial effects on bone health. |
| first_indexed | 2024-03-10T17:08:06Z |
| format | Article |
| id | doaj.art-aa739a6122d64eeb977d046ba4f743b6 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-10T17:08:06Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
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| series | Journal of Translational Medicine |
| spelling | doaj.art-aa739a6122d64eeb977d046ba4f743b62023-11-20T10:44:57ZengBMCJournal of Translational Medicine1479-58762023-08-0121111310.1186/s12967-023-04397-9BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018Jiacheng Wang0Yi Zheng1Yawen Wang2Chengjun Zhang3Yanfeng Jiang4Chen Suo5Mei Cui6Tiejun Zhang7Xingdong Chen8Kelin Xu9School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityState Key Laboratory of Genetic Engineering, Human Phenome Institute, Fudan UniversitySchool of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversitySchool of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityState Key Laboratory of Genetic Engineering, Human Phenome Institute, Fudan UniversitySchool of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityDepartment of Neurology, Huashan Hospital, Fudan UniversitySchool of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityState Key Laboratory of Genetic Engineering, Human Phenome Institute, Fudan UniversitySchool of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityAbstract Background Studies have examined the effect of weight change on osteoporosis, but the results were controversial. Among them, few had looked at weight change over the life span. This study aimed to fill this gap and investigate the association between lifetime body mass index (BMI) trajectories and bone loss. Methods In this cross-sectional study, participants at age 50 and above were selected from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Dual-energy X-ray Absorptiometry was used to measure the bone mineral density at the femoral neck and lumbar spine. Standard BMI criteria were used, with < 25 kg/m2 for normal, 25–29.9 kg/m2 for overweight, and ≥ 30 kg/m2 for obesity. The latent class trajectory model (LCTM) was used to identify BMI trajectories. Multinomial logistic regression models were fitted to evaluate the association between different BMI trajectories and osteoporosis or osteopenia. Results For the 9,706 eligible participants, we identified four BMI trajectories, including stable (n = 7,681, 70.14%), slight increase (n = 1253, 12.91%), increase to decrease (n = 195, 2.01%), and rapid increase (n = 577, 5.94%). Compared with individuals in the stable trajectory, individuals in the rapid increase trajectory had higher odds of osteoporosis (OR = 2.25, 95% CI 1.19–4.23) and osteopenia (OR = 1.49, 95% CI 1.02–2.17). This association was only found in the lumbar spine (OR = 2.11, 95% CI 1.06–4.2) but not in the femoral neck. In early-stage (age 25–10 years ago) weight change, staying an obesity and stable weight seemed to have protective effects on osteoporosis (OR = 0.26, 95% CI 0.08–0.77) and osteopenia (OR = 0.46, 95% CI 0.25–0.84). Meanwhile, keeping an early-stage stable and overweight was related to lower odds of osteopenia (OR = 0.53, 95% CI 0.34–0.83). No statistically significant association between recent (10 years ago to baseline) weight change and osteoporosis was found. Conclusions Rapid and excess weight gain during adulthood is associated with a higher risk of osteoporosis. But this association varies by skeletal sites. Maintaining stable overweight and obesity at an early stage may have potentially beneficial effects on bone health.https://doi.org/10.1186/s12967-023-04397-9Body mass indexWeight changeOsteoporosisBone mineral densityNHANES |
| spellingShingle | Jiacheng Wang Yi Zheng Yawen Wang Chengjun Zhang Yanfeng Jiang Chen Suo Mei Cui Tiejun Zhang Xingdong Chen Kelin Xu BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018 Journal of Translational Medicine Body mass index Weight change Osteoporosis Bone mineral density NHANES |
| title | BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018 |
| title_full | BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018 |
| title_fullStr | BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018 |
| title_full_unstemmed | BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018 |
| title_short | BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018 |
| title_sort | bmi trajectory of rapid and excessive weight gain during adulthood is associated with bone loss a cross sectional study from nhanes 2005 2018 |
| topic | Body mass index Weight change Osteoporosis Bone mineral density NHANES |
| url | https://doi.org/10.1186/s12967-023-04397-9 |
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