Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.)
Asiaticoside, a pentacyclic triterpene of Centella asiatica with broad pharmacological actions. Higher asiaticoside content of Centella extracts in food products increases their nutritional and medicinal values. Protic ionic liquids (PIL) were utilized as bioactive extraction additives. The research...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of King Saud University: Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364723003257 |
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| author | Zetty Shafiqa Othman Mohamad Yusof Maskat Nadhratun Naiim Mobarak Rozida Mohd Khalid Shikh Mohd Shahrul Nizan Shikh Zahari Nur Hasyareeda Hassan |
| author_facet | Zetty Shafiqa Othman Mohamad Yusof Maskat Nadhratun Naiim Mobarak Rozida Mohd Khalid Shikh Mohd Shahrul Nizan Shikh Zahari Nur Hasyareeda Hassan |
| author_sort | Zetty Shafiqa Othman |
| collection | DOAJ |
| description | Asiaticoside, a pentacyclic triterpene of Centella asiatica with broad pharmacological actions. Higher asiaticoside content of Centella extracts in food products increases their nutritional and medicinal values. Protic ionic liquids (PIL) were utilized as bioactive extraction additives. The research focuses on obtaining the optimum extraction parameters for higher asiaticoside yield, and Centella extract antioxidant capacity. Optimization of all responses (asiaticoside yield, TPC, TEAC) achieved through faced-centered composite design (FCCD) involving three factors (temperature, extraction time, and triethylammonium hydrogen sulfate, [TEA][HSO4] %). The optimal conditions were 66 °C, 12 h duration, and 20% [TEA][HSO4], which resulted in 4.44 ± 0.05% (w/w) asiaticoside, TPC of 114.11 ± 12.58 mg GAE /g and TEAC of 70.01 ± 5.74 µmol TE/g respectively. All responses fit the quadratic model with proximity between predicted and experimented values. Procurement of higher asiaticoside yield, TPC, and TEAC verified the pertinent of the optimal conditions. In addition, the outcomes give an overview of PILs potential for higher bioactive extractions. Research expansion by utilizing other PILs for plant extraction in addition to solute–solvent interaction study will be beneficial for the designation of an efficient plant extraction process that maximizes the plant-based product market. |
| first_indexed | 2024-03-11T16:52:37Z |
| format | Article |
| id | doaj.art-aa74210146234af5b0ed02cdb7150a28 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-03-11T16:52:37Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-aa74210146234af5b0ed02cdb7150a282023-10-21T04:22:07ZengElsevierJournal of King Saud University: Science1018-36472023-11-01358102863Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.)Zetty Shafiqa Othman0Mohamad Yusof Maskat1Nadhratun Naiim Mobarak2Rozida Mohd Khalid3Shikh Mohd Shahrul Nizan Shikh Zahari4Nur Hasyareeda Hassan5Department of Chemical Sciences, Faculty of Science and Technology Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, MalaysiaDepartment of Food Sciences, Faculty of Science and Technology Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, MalaysiaDepartment of Chemical Sciences, Faculty of Science and Technology Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, MalaysiaDepartment of Chemical Sciences, Faculty of Science and Technology Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, MalaysiaFaculty of Science and Technology, Universiti Sains Islam Malaysia, 71800 Bandar Baru Nilai, Negeri Sembilan, Malaysia; Department of Chemical Engineering, South Kensington Campus, Imperial College London, Exhibition Rd, South Kensington, London SW7 2AZ, United Kingdom; Corresponding author at: Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.Department of Chemical Sciences, Faculty of Science and Technology Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia; Corresponding author at: Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.Asiaticoside, a pentacyclic triterpene of Centella asiatica with broad pharmacological actions. Higher asiaticoside content of Centella extracts in food products increases their nutritional and medicinal values. Protic ionic liquids (PIL) were utilized as bioactive extraction additives. The research focuses on obtaining the optimum extraction parameters for higher asiaticoside yield, and Centella extract antioxidant capacity. Optimization of all responses (asiaticoside yield, TPC, TEAC) achieved through faced-centered composite design (FCCD) involving three factors (temperature, extraction time, and triethylammonium hydrogen sulfate, [TEA][HSO4] %). The optimal conditions were 66 °C, 12 h duration, and 20% [TEA][HSO4], which resulted in 4.44 ± 0.05% (w/w) asiaticoside, TPC of 114.11 ± 12.58 mg GAE /g and TEAC of 70.01 ± 5.74 µmol TE/g respectively. All responses fit the quadratic model with proximity between predicted and experimented values. Procurement of higher asiaticoside yield, TPC, and TEAC verified the pertinent of the optimal conditions. In addition, the outcomes give an overview of PILs potential for higher bioactive extractions. Research expansion by utilizing other PILs for plant extraction in addition to solute–solvent interaction study will be beneficial for the designation of an efficient plant extraction process that maximizes the plant-based product market.http://www.sciencedirect.com/science/article/pii/S1018364723003257Triethylammonium hydrogen sulfateAsiaticosidePhenolic compoundsAntioxidantOptimization |
| spellingShingle | Zetty Shafiqa Othman Mohamad Yusof Maskat Nadhratun Naiim Mobarak Rozida Mohd Khalid Shikh Mohd Shahrul Nizan Shikh Zahari Nur Hasyareeda Hassan Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.) Journal of King Saud University: Science Triethylammonium hydrogen sulfate Asiaticoside Phenolic compounds Antioxidant Optimization |
| title | Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.) |
| title_full | Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.) |
| title_fullStr | Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.) |
| title_full_unstemmed | Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.) |
| title_short | Utilization of triethylammonium hydrogen sulphate-mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of Centella asiatica (L.) |
| title_sort | utilization of triethylammonium hydrogen sulphate mediated solvent for optimization of asiaticoside extraction and antioxidant capacity of centella asiatica l |
| topic | Triethylammonium hydrogen sulfate Asiaticoside Phenolic compounds Antioxidant Optimization |
| url | http://www.sciencedirect.com/science/article/pii/S1018364723003257 |
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