Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study
BackgroundPrevious studies have found that exposure to heavy metals increased the incidence of congenital heart defects (CHDs). However, there is a paucity of information about the connection between exposure to titanium and CHDs. This study sought to examine the relationship between prenatal titani...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.946439/full |
| _version_ | 1818010939732000768 |
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| author | Jianhao Sun Jianhao Sun Baohong Mao Zhenzhen Wu Xinjuan Jiao Yanxia Wang Yongli Lu Xuejing Ma Xiaohui Liu Xiaoying Xu Hongmei Cui Xiaojuan Lin Bin Yi Jie Qiu Qing Liu Qing Liu |
| author_facet | Jianhao Sun Jianhao Sun Baohong Mao Zhenzhen Wu Xinjuan Jiao Yanxia Wang Yongli Lu Xuejing Ma Xiaohui Liu Xiaoying Xu Hongmei Cui Xiaojuan Lin Bin Yi Jie Qiu Qing Liu Qing Liu |
| author_sort | Jianhao Sun |
| collection | DOAJ |
| description | BackgroundPrevious studies have found that exposure to heavy metals increased the incidence of congenital heart defects (CHDs). However, there is a paucity of information about the connection between exposure to titanium and CHDs. This study sought to examine the relationship between prenatal titanium exposure and the risk of CHDs in offspring.MethodsWe looked back on a birth cohort study that was carried out in our hospital between 2010 and 2012. The associations between titanium exposure and the risk of CHDs were analyzed by using logistic regression analysis to investigate titanium concentrations in maternal whole blood and fetal umbilical cord blood.ResultsA total of 97 case groups and 194 control groups were included for a nested case-control study. The [P50 (P25, P75)] of titanium were 371.91 (188.85, 659.15) μg/L and 370.43 (264.86, 459.76) μg/L in serum titanium levels in pregnant women and in umbilical cord serum titanium content in the CHDs group, respectively. There was a moderate positive correlation between the concentration of titanium in pregnant women's blood and that in umbilical cord blood. A higher concentrations of maternal blood titanium level was associated with a greater risk of CHDs (OR 2.706, 95% CI 1.547–4.734), the multiple CHDs (OR 2.382, 95% CI 1.219–4.655), atrial septal defects (OR 2.367, 95% CI 1.215–4.609), and patent ductus arteriosus (OR 2.412, 95% CI 1.336–4.357). Dramatically higher concentrations of umbilical cord blood levels had an increased risk of CHDs and different heart defects.ConclusionTitanium can cross the placental barrier and the occurrence of CHDs may be related to titanium exposure. |
| first_indexed | 2024-04-14T06:01:55Z |
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| id | doaj.art-aa751a4967104f90a7cebbaa2c06061b |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-14T06:01:55Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-aa751a4967104f90a7cebbaa2c06061b2022-12-22T02:08:44ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-08-011010.3389/fpubh.2022.946439946439Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control studyJianhao Sun0Jianhao Sun1Baohong Mao2Zhenzhen Wu3Xinjuan Jiao4Yanxia Wang5Yongli Lu6Xuejing Ma7Xiaohui Liu8Xiaoying Xu9Hongmei Cui10Xiaojuan Lin11Bin Yi12Jie Qiu13Qing Liu14Qing Liu15Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaSchool of Nursing, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaGansu Provincial Maternity and Child-Care Hospital, Lanzhou, ChinaThe First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, ChinaBackgroundPrevious studies have found that exposure to heavy metals increased the incidence of congenital heart defects (CHDs). However, there is a paucity of information about the connection between exposure to titanium and CHDs. This study sought to examine the relationship between prenatal titanium exposure and the risk of CHDs in offspring.MethodsWe looked back on a birth cohort study that was carried out in our hospital between 2010 and 2012. The associations between titanium exposure and the risk of CHDs were analyzed by using logistic regression analysis to investigate titanium concentrations in maternal whole blood and fetal umbilical cord blood.ResultsA total of 97 case groups and 194 control groups were included for a nested case-control study. The [P50 (P25, P75)] of titanium were 371.91 (188.85, 659.15) μg/L and 370.43 (264.86, 459.76) μg/L in serum titanium levels in pregnant women and in umbilical cord serum titanium content in the CHDs group, respectively. There was a moderate positive correlation between the concentration of titanium in pregnant women's blood and that in umbilical cord blood. A higher concentrations of maternal blood titanium level was associated with a greater risk of CHDs (OR 2.706, 95% CI 1.547–4.734), the multiple CHDs (OR 2.382, 95% CI 1.219–4.655), atrial septal defects (OR 2.367, 95% CI 1.215–4.609), and patent ductus arteriosus (OR 2.412, 95% CI 1.336–4.357). Dramatically higher concentrations of umbilical cord blood levels had an increased risk of CHDs and different heart defects.ConclusionTitanium can cross the placental barrier and the occurrence of CHDs may be related to titanium exposure.https://www.frontiersin.org/articles/10.3389/fpubh.2022.946439/fullcongenital heart defectsmetal exposuretitaniumpregnancymaternal bloodumbilical cord blood |
| spellingShingle | Jianhao Sun Jianhao Sun Baohong Mao Zhenzhen Wu Xinjuan Jiao Yanxia Wang Yongli Lu Xuejing Ma Xiaohui Liu Xiaoying Xu Hongmei Cui Xiaojuan Lin Bin Yi Jie Qiu Qing Liu Qing Liu Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study Frontiers in Public Health congenital heart defects metal exposure titanium pregnancy maternal blood umbilical cord blood |
| title | Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study |
| title_full | Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study |
| title_fullStr | Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study |
| title_full_unstemmed | Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study |
| title_short | Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study |
| title_sort | relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in lanzhou china a nested case control study |
| topic | congenital heart defects metal exposure titanium pregnancy maternal blood umbilical cord blood |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.946439/full |
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