A Penicillin Derivative Exerts an Anti-Metastatic Activity in Melanoma Cells Through the Downregulation of Integrin αvβ3 and Wnt/β-Catenin Pathway

A Penicillin Derivative Exerts an Anti-Metastatic Activity in Melanoma Cells Through the Downregulation of Integrin αvβ3 and Wnt/β-Catenin Pathway

The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of this compound on highly metastatic murine B16-F10...

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Bibliographic Details
Main Authors: Elizabeth Barrionuevo, Florencia Cayrol, Graciela A. Cremaschi, Patricia G. Cornier, Dora B. Boggián, Carina M. L. Delpiccolo, Ernesto G. Mata, Leonor P. Roguin, Viviana C. Blank
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
triazolylpeptidyl penicillin
anti-metastatic effect
murine melanoma
β-catenin
metalloproteinases-2 and -9
integrin αvβ3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00127/full

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