Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation
Introduction. A sudden withdrawal of antiepileptic drugs gives higher rate of epileptic seizures in the settings of video electroencephalography (vEEG), monitoring that is a subject to further registration and analysis. A very rare complication of this method is transient lesion of the splenium of c...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2010-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501005427R.pdf |
| _version_ | 1811194930655133696 |
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| author | Ristić Aleksandar Lavrnić Slobodan Zović Ljubica Vojvodić Nikola Janković Slavko Škrijelj Fadilj Ercegovac Marko Sokić Dragoslav |
| author_facet | Ristić Aleksandar Lavrnić Slobodan Zović Ljubica Vojvodić Nikola Janković Slavko Škrijelj Fadilj Ercegovac Marko Sokić Dragoslav |
| author_sort | Ristić Aleksandar |
| collection | DOAJ |
| description | Introduction. A sudden withdrawal of antiepileptic drugs gives higher rate of epileptic seizures in the settings of video electroencephalography (vEEG), monitoring that is a subject to further registration and analysis. A very rare complication of this method is transient lesion of the splenium of corpus callosum (SCC) detected with brain MRI. Case report. We presented a patient with a 5-year history of pharmacoresistant epilepsy admitted to the Institute of Neurology (August, 2008) for vEEG monitoring. Interictal epileptic discharges but none seizure were recorded after the sudden withdrawal of antiepileptic medications, during 5 days of vEEG monitoring Initial brain MRI three days after vEEG monitoring revealed focal lesion in SCC, hyperintense on T2 and FLAIR sequence. A longitudinal radiological follow-up (7 and 49 days after initial acquisition) confirmed transient nature of the lesion without diffusion coefficient changes. Conclusion. SCC lesion, reversible and harmless, may occur after a sudden antiepileptic withdrawal. Its early detection makes further extensive neuroradiological and clinical examinations unnecessary. |
| first_indexed | 2024-04-12T00:35:30Z |
| format | Article |
| id | doaj.art-aa77a3a066544936a11cbb826e90f66c |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-04-12T00:35:30Z |
| publishDate | 2010-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-aa77a3a066544936a11cbb826e90f66c2022-12-22T03:55:11ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502010-01-0167542743010.2298/VSP1005427RTransient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluationRistić AleksandarLavrnić SlobodanZović LjubicaVojvodić NikolaJanković SlavkoŠkrijelj FadiljErcegovac MarkoSokić DragoslavIntroduction. A sudden withdrawal of antiepileptic drugs gives higher rate of epileptic seizures in the settings of video electroencephalography (vEEG), monitoring that is a subject to further registration and analysis. A very rare complication of this method is transient lesion of the splenium of corpus callosum (SCC) detected with brain MRI. Case report. We presented a patient with a 5-year history of pharmacoresistant epilepsy admitted to the Institute of Neurology (August, 2008) for vEEG monitoring. Interictal epileptic discharges but none seizure were recorded after the sudden withdrawal of antiepileptic medications, during 5 days of vEEG monitoring Initial brain MRI three days after vEEG monitoring revealed focal lesion in SCC, hyperintense on T2 and FLAIR sequence. A longitudinal radiological follow-up (7 and 49 days after initial acquisition) confirmed transient nature of the lesion without diffusion coefficient changes. Conclusion. SCC lesion, reversible and harmless, may occur after a sudden antiepileptic withdrawal. Its early detection makes further extensive neuroradiological and clinical examinations unnecessary.http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501005427R.pdfepilepsiespartialanticonvulsantsmagneticresonance imagingelectroencephalographycorpuscallosumischemic attacktransient |
| spellingShingle | Ristić Aleksandar Lavrnić Slobodan Zović Ljubica Vojvodić Nikola Janković Slavko Škrijelj Fadilj Ercegovac Marko Sokić Dragoslav Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation Vojnosanitetski Pregled epilepsies partial anticonvulsants magneticresonance imaging electroencephalography corpuscallosum ischemic attack transient |
| title | Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation |
| title_full | Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation |
| title_fullStr | Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation |
| title_full_unstemmed | Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation |
| title_short | Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation |
| title_sort | transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal a case with focal epilepsy in presurgical evaluation |
| topic | epilepsies partial anticonvulsants magneticresonance imaging electroencephalography corpuscallosum ischemic attack transient |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501005427R.pdf |
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