Interactions between FGF23 and vitamin D
Fibroblast growth factor‐23 (FGF23) controls the homeostasis of both phosphate and vitamin D. Bone-derived FGF23 can suppress the transcription of 1α‐hydroxylase (1α(OH)ase) to reduce renal activation of vitamin D (1,25(OH)2D3). FGF23 can also activate the transcription of 24‐hydroxylase to enhance...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-09-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/11/10/EC-22-0239.xml |
| _version_ | 1811204065164525568 |
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| author | Mohammed S Razzaque |
| author_facet | Mohammed S Razzaque |
| author_sort | Mohammed S Razzaque |
| collection | DOAJ |
| description | Fibroblast growth factor‐23 (FGF23) controls the homeostasis of both phosphate and vitamin D. Bone-derived FGF23 can suppress the transcription of 1α‐hydroxylase (1α(OH)ase) to reduce renal activation of vitamin D (1,25(OH)2D3). FGF23 can also activate the transcription of 24‐hydroxylase to enhance the renal degradation process of vitamin D. There is a counter-regulation for FGF23 and vitamin D; 1,25(OH)2D3 induces the skeletal synthesis and the release of FGF23, while FGF23 can suppress the production of 1,25(OH)2D3 by inhibiting 1α(OH)ase synthesis. Genetically ablating FGF23 activities in mice resulted in higher levels of renal 1α(OH)ase, which is also reflected in an increased level of serum 1,25(OH)2D3, while genetically ablating 1α(OH)ase activities in mice reduced the serum levels of FGF23. Similar feedback control of FGF23 and vitamin D is also detected in various human diseases. Further studies are required to understand the subcellular molecular regulation of FGF23 and vitamin D in health and disease. |
| first_indexed | 2024-04-12T03:05:12Z |
| format | Article |
| id | doaj.art-aa7b63a50a9b403da7fc769dc040bb85 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-12T03:05:12Z |
| publishDate | 2022-09-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-aa7b63a50a9b403da7fc769dc040bb852022-12-22T03:50:31ZengBioscientificaEndocrine Connections2049-36142022-09-01111017https://doi.org/10.1530/EC-22-0239Interactions between FGF23 and vitamin DMohammed S Razzaque0Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, USAFibroblast growth factor‐23 (FGF23) controls the homeostasis of both phosphate and vitamin D. Bone-derived FGF23 can suppress the transcription of 1α‐hydroxylase (1α(OH)ase) to reduce renal activation of vitamin D (1,25(OH)2D3). FGF23 can also activate the transcription of 24‐hydroxylase to enhance the renal degradation process of vitamin D. There is a counter-regulation for FGF23 and vitamin D; 1,25(OH)2D3 induces the skeletal synthesis and the release of FGF23, while FGF23 can suppress the production of 1,25(OH)2D3 by inhibiting 1α(OH)ase synthesis. Genetically ablating FGF23 activities in mice resulted in higher levels of renal 1α(OH)ase, which is also reflected in an increased level of serum 1,25(OH)2D3, while genetically ablating 1α(OH)ase activities in mice reduced the serum levels of FGF23. Similar feedback control of FGF23 and vitamin D is also detected in various human diseases. Further studies are required to understand the subcellular molecular regulation of FGF23 and vitamin D in health and disease.https://ec.bioscientifica.com/view/journals/ec/11/10/EC-22-0239.xmlvitamin d1α(oh)asefgf23klothopth |
| spellingShingle | Mohammed S Razzaque Interactions between FGF23 and vitamin D Endocrine Connections vitamin d 1α(oh)ase fgf23 klotho pth |
| title | Interactions between FGF23 and vitamin D |
| title_full | Interactions between FGF23 and vitamin D |
| title_fullStr | Interactions between FGF23 and vitamin D |
| title_full_unstemmed | Interactions between FGF23 and vitamin D |
| title_short | Interactions between FGF23 and vitamin D |
| title_sort | interactions between fgf23 and vitamin d |
| topic | vitamin d 1α(oh)ase fgf23 klotho pth |
| url | https://ec.bioscientifica.com/view/journals/ec/11/10/EC-22-0239.xml |
| work_keys_str_mv | AT mohammedsrazzaque interactionsbetweenfgf23andvitamind |