Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient
Creutzfeldt-Jakob Disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disorder. We describe a man whose initial manifestations of CJD occurred shortly after contracting Coronavirus disease 2019 (COVID-19). He first developed anxiety and short-term memory loss a few weeks after...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1239576/full |
| _version_ | 1797752215607181312 |
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| author | Christl S. K. Yong Ethan Jian-Hui Maniam Cheryl W. L. Chang Jonathan Yexian Lai Cyrus Su Hui Ho Cyrus Su Hui Ho |
| author_facet | Christl S. K. Yong Ethan Jian-Hui Maniam Cheryl W. L. Chang Jonathan Yexian Lai Cyrus Su Hui Ho Cyrus Su Hui Ho |
| author_sort | Christl S. K. Yong |
| collection | DOAJ |
| description | Creutzfeldt-Jakob Disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disorder. We describe a man whose initial manifestations of CJD occurred shortly after contracting Coronavirus disease 2019 (COVID-19). He first developed anxiety and short-term memory loss a few weeks after a mild COVID-19 infection. He subsequently developed parkinsonism, eventually progressed to akinetic mutism, and passed away 5 months after symptom onset. This case highlights a potential temporal relationship between COVID-19 infection and the onset of neurodegenerative symptoms. Microglia and astrocytes in the central nervous system (CNS) and ‘S1’ spike proteins on SARS-CoV-2 are potential mediators in neuroinflammation and neurodegeneration. |
| first_indexed | 2024-03-12T17:01:05Z |
| format | Article |
| id | doaj.art-aa7c6d8b84c74cf496322b028f51e39d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T17:01:05Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-aa7c6d8b84c74cf496322b028f51e39d2023-08-07T14:42:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.12395761239576Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patientChristl S. K. Yong0Ethan Jian-Hui Maniam1Cheryl W. L. Chang2Jonathan Yexian Lai3Cyrus Su Hui Ho4Cyrus Su Hui Ho5Department of Psychological Medicine, National University Health System, Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Psychological Medicine, National University Health System, Singapore, SingaporeDepartment of Neurology, National Neuroscience Institute, Duke-NUS Medical School, Singapore, SingaporeDepartment of Psychological Medicine, National University Health System, Singapore, SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeCreutzfeldt-Jakob Disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disorder. We describe a man whose initial manifestations of CJD occurred shortly after contracting Coronavirus disease 2019 (COVID-19). He first developed anxiety and short-term memory loss a few weeks after a mild COVID-19 infection. He subsequently developed parkinsonism, eventually progressed to akinetic mutism, and passed away 5 months after symptom onset. This case highlights a potential temporal relationship between COVID-19 infection and the onset of neurodegenerative symptoms. Microglia and astrocytes in the central nervous system (CNS) and ‘S1’ spike proteins on SARS-CoV-2 are potential mediators in neuroinflammation and neurodegeneration.https://www.frontiersin.org/articles/10.3389/fneur.2023.1239576/fullcase reportCreutzfeldt-Jakob diseaseCOVID-19anxietyinflammation |
| spellingShingle | Christl S. K. Yong Ethan Jian-Hui Maniam Cheryl W. L. Chang Jonathan Yexian Lai Cyrus Su Hui Ho Cyrus Su Hui Ho Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient Frontiers in Neurology case report Creutzfeldt-Jakob disease COVID-19 anxiety inflammation |
| title | Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient |
| title_full | Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient |
| title_fullStr | Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient |
| title_full_unstemmed | Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient |
| title_short | Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient |
| title_sort | case report creutzfeldt jakob disease presenting with anxiety symptoms in a covid 19 post infection patient |
| topic | case report Creutzfeldt-Jakob disease COVID-19 anxiety inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1239576/full |
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