Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans
ABSTRACTBackground Dental caries is a chronic, multifactorial and biofilm-mediated oral bacterial infection affecting almost every age group and every geographical region. Streptococcus mutans is considered an important pathogen responsible for the initiation and development of dental caries. It pro...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2023.2225257 |
| _version_ | 1827632213568520192 |
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| author | Ting Zheng Meiling Jing Tao Gong Jiangchuan Yan Xiaowan Wang Mai Xu Xuedong Zhou Jumei Zeng Yuqing Li |
| author_facet | Ting Zheng Meiling Jing Tao Gong Jiangchuan Yan Xiaowan Wang Mai Xu Xuedong Zhou Jumei Zeng Yuqing Li |
| author_sort | Ting Zheng |
| collection | DOAJ |
| description | ABSTRACTBackground Dental caries is a chronic, multifactorial and biofilm-mediated oral bacterial infection affecting almost every age group and every geographical region. Streptococcus mutans is considered an important pathogen responsible for the initiation and development of dental caries. It produces exopolysaccharides in situ to promote the colonization of cariogenic bacteria and coordinate dental biofilm development.Objective The understanding of the regulatory mechanism of S. mutans biofilm formation can provide a theoretical basis for the prevention and treatment of caries.Design At present, an increasing number of studies have identified many regulatory systems in S. mutans that regulate biofilm formation, including second messengers (e.g. c-di-AMP, Ap4A), transcription factors (e.g. EpsR, RcrR, StsR, AhrC, FruR), two-component systems (e.g. CovR, VicR), small RNA (including sRNA0426, srn92532, and srn133489), acetylation modifications (e.g. ActG), CRISPR-associated proteins (e.g. Cas3), PTS systems (e.g. EIIAB), quorum-sensing signaling system (e.g. LuxS), enzymes (including Dex, YidC, CopZ, EzrA, lmrB, SprV, RecA, PdxR, MurI) and small-molecule metabolites.Results This review summarizes the recent progress in the molecular regulatory mechanisms of exopolysaccharides synthesis and biofilm formation in S. mutans. |
| first_indexed | 2024-03-09T14:32:53Z |
| format | Article |
| id | doaj.art-aa7cb8a008db4c4e8568a94c4b52999b |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-03-09T14:32:53Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-aa7cb8a008db4c4e8568a94c4b52999b2023-11-27T17:25:00ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972023-12-0115110.1080/20002297.2023.2225257Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutansTing Zheng0Meiling Jing1Tao Gong2Jiangchuan Yan3Xiaowan Wang4Mai Xu5Xuedong Zhou6Jumei Zeng7Yuqing Li8State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaABSTRACTBackground Dental caries is a chronic, multifactorial and biofilm-mediated oral bacterial infection affecting almost every age group and every geographical region. Streptococcus mutans is considered an important pathogen responsible for the initiation and development of dental caries. It produces exopolysaccharides in situ to promote the colonization of cariogenic bacteria and coordinate dental biofilm development.Objective The understanding of the regulatory mechanism of S. mutans biofilm formation can provide a theoretical basis for the prevention and treatment of caries.Design At present, an increasing number of studies have identified many regulatory systems in S. mutans that regulate biofilm formation, including second messengers (e.g. c-di-AMP, Ap4A), transcription factors (e.g. EpsR, RcrR, StsR, AhrC, FruR), two-component systems (e.g. CovR, VicR), small RNA (including sRNA0426, srn92532, and srn133489), acetylation modifications (e.g. ActG), CRISPR-associated proteins (e.g. Cas3), PTS systems (e.g. EIIAB), quorum-sensing signaling system (e.g. LuxS), enzymes (including Dex, YidC, CopZ, EzrA, lmrB, SprV, RecA, PdxR, MurI) and small-molecule metabolites.Results This review summarizes the recent progress in the molecular regulatory mechanisms of exopolysaccharides synthesis and biofilm formation in S. mutans.https://www.tandfonline.com/doi/10.1080/20002297.2023.2225257Dental cariesstreptococcus mutansbiofilm formationexopolysaccharides synthesisregulatory mechanism |
| spellingShingle | Ting Zheng Meiling Jing Tao Gong Jiangchuan Yan Xiaowan Wang Mai Xu Xuedong Zhou Jumei Zeng Yuqing Li Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans Journal of Oral Microbiology Dental caries streptococcus mutans biofilm formation exopolysaccharides synthesis regulatory mechanism |
| title | Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans |
| title_full | Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans |
| title_fullStr | Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans |
| title_full_unstemmed | Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans |
| title_short | Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans |
| title_sort | regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in streptococcus mutans |
| topic | Dental caries streptococcus mutans biofilm formation exopolysaccharides synthesis regulatory mechanism |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2023.2225257 |
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