Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry
A multi-residue method has been developed for the identification and quantification of 103 common veterinary drug residues in milk and dairy Products. This method was based on QuEChERS with dispersive solid-phase where C18 sorbent and anhydrous sodium sulfate were used to sample purification. After...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.879518/full |
| _version_ | 1811288624996548608 |
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| author | Xiujuan Guo Hao Tian Fan Yang Sufang Fan Jingwen Zhang Junmei Ma Lianfeng Ai Yan Zhang Yan Zhang |
| author_facet | Xiujuan Guo Hao Tian Fan Yang Sufang Fan Jingwen Zhang Junmei Ma Lianfeng Ai Yan Zhang Yan Zhang |
| author_sort | Xiujuan Guo |
| collection | DOAJ |
| description | A multi-residue method has been developed for the identification and quantification of 103 common veterinary drug residues in milk and dairy Products. This method was based on QuEChERS with dispersive solid-phase where C18 sorbent and anhydrous sodium sulfate were used to sample purification. After evaporation and reconstitution, the samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. The mean recovery results were all higher than 60% except ampicillin, pipemidic acid, enoxacin, and estriol, and the relative standard deviation was <20.0%. The limit of quantification ranged between 0.1 and 5 μg/kg for milk and between 0.5 and 25 μg/kg for milk powder. It was successfully used to detect residues of veterinary drug in real samples. This study proposes a simple and fast analytical method for monitoring multi-class veterinary drug residues to ensure food safety. |
| first_indexed | 2024-04-13T03:40:35Z |
| format | Article |
| id | doaj.art-aa7cd931d78346319a78c213e94b1e97 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T03:40:35Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-aa7cd931d78346319a78c213e94b1e972022-12-22T03:04:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-07-01910.3389/fnut.2022.879518879518Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometryXiujuan Guo0Hao Tian1Fan Yang2Sufang Fan3Jingwen Zhang4Junmei Ma5Lianfeng Ai6Yan Zhang7Yan Zhang8Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaTechnology Center of Shijiazhuang Customs District, Shijiazhuang, ChinaHebei Food Inspection and Research Institute, Shijiazhuang, ChinaHebei Food Inspection and Research Institute, Shijiazhuang, ChinaHebei Food Inspection and Research Institute, Shijiazhuang, ChinaHebei Food Inspection and Research Institute, Shijiazhuang, ChinaTechnology Center of Shijiazhuang Customs District, Shijiazhuang, ChinaHebei Food Inspection and Research Institute, Shijiazhuang, ChinaHebei Key Laboratory of Forensic Medicine, College of Forensic Medicine, Hebei Medical University, Shijiazhuang, ChinaA multi-residue method has been developed for the identification and quantification of 103 common veterinary drug residues in milk and dairy Products. This method was based on QuEChERS with dispersive solid-phase where C18 sorbent and anhydrous sodium sulfate were used to sample purification. After evaporation and reconstitution, the samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. The mean recovery results were all higher than 60% except ampicillin, pipemidic acid, enoxacin, and estriol, and the relative standard deviation was <20.0%. The limit of quantification ranged between 0.1 and 5 μg/kg for milk and between 0.5 and 25 μg/kg for milk powder. It was successfully used to detect residues of veterinary drug in real samples. This study proposes a simple and fast analytical method for monitoring multi-class veterinary drug residues to ensure food safety.https://www.frontiersin.org/articles/10.3389/fnut.2022.879518/fullrapid detectionveterinary drug residuesmilkdairy productsUPLC-MS/MS |
| spellingShingle | Xiujuan Guo Hao Tian Fan Yang Sufang Fan Jingwen Zhang Junmei Ma Lianfeng Ai Yan Zhang Yan Zhang Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry Frontiers in Nutrition rapid detection veterinary drug residues milk dairy products UPLC-MS/MS |
| title | Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry |
| title_full | Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry |
| title_fullStr | Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry |
| title_full_unstemmed | Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry |
| title_short | Rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry |
| title_sort | rapid determination of 103 common veterinary drug residues in milk and dairy products by ultra performance liquid chromatography tandem mass spectrometry |
| topic | rapid detection veterinary drug residues milk dairy products UPLC-MS/MS |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.879518/full |
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