Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends
Abstract Background Lung adenocarcinomas with micropapillary pattern (MP) or solid pattern (SP) have poor prognosis with frequent postoperative recurrence. However, treatment strategies for these histological subtypes have not been established. This study examined the recurrence rates and patterns i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15087 |
| _version_ | 1797649727922110464 |
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| author | Naoki Takeno Shintaro Tarumi Masahiro Abe Yasuhiro Suzuki Ichiro Kinoshita Tatsuya Kato |
| author_facet | Naoki Takeno Shintaro Tarumi Masahiro Abe Yasuhiro Suzuki Ichiro Kinoshita Tatsuya Kato |
| author_sort | Naoki Takeno |
| collection | DOAJ |
| description | Abstract Background Lung adenocarcinomas with micropapillary pattern (MP) or solid pattern (SP) have poor prognosis with frequent postoperative recurrence. However, treatment strategies for these histological subtypes have not been established. This study examined the recurrence rates and patterns in patients with these histological subtypes. Methods Overall, 238 patients with lung adenocarcinoma who underwent radical resection were included. According to the histological subtypes, the patients were classified into three groups: neither MP nor SP (MP−/SP−), MP (MP+), and SP (SP+). The clinical and pathological characteristics and recurrence‐free survival (RFS) were examined in each group. In addition, univariate and multivariate analyses were performed to investigate the recurrence factors. The site of recurrence, PD‐L1 expression, and driver mutations were examined in patients with postoperative recurrence. Results The recurrence rates were significantly higher in the MP+ and SP+ groups (p = 0.01). The RFS was significantly shorter in the MP+ and SP+ groups (p < 0.001) than in the MP−/SP− group, especially in pStage 1A (p = 0.001). The relationship between recurrence and pathologic factors was significant for pleural, lymphatic, and vascular invasion, as well as MP in univariate analysis and only for MP in multivariate analysis. Most recurrences were distant metastases in the MP+ and SP+ groups. PD‐L1 was highly expressed in recurrent SP+ cases. Conclusions Early‐stage lung adenocarcinoma with MP or SP frequently has postoperative recurrence. Prevention of distant metastases is important in these patients to improve prognosis, and aggressive postoperative chemotherapy may be considered. |
| first_indexed | 2024-03-11T15:51:13Z |
| format | Article |
| id | doaj.art-aa7d9117cf284a488f42e5151645c628 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-11T15:51:13Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-aa7d9117cf284a488f42e5151645c6282023-10-26T00:21:42ZengWileyThoracic Cancer1759-77061759-77142023-10-0114302987299210.1111/1759-7714.15087Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trendsNaoki Takeno0Shintaro Tarumi1Masahiro Abe2Yasuhiro Suzuki3Ichiro Kinoshita4Tatsuya Kato5Department of Thoracic Surgery Keiyukai Sapporo Hospital Sapporo JapanDepartment of Thoracic Surgery Keiyukai Sapporo Hospital Sapporo JapanDepartment of Thoracic Surgery Keiyukai Sapporo Hospital Sapporo JapanDepartment of Thoracic Surgery Keiyukai Sapporo Hospital Sapporo JapanDepartment of Medical Oncology Hokkaido University Sapporo JapanDepartment of Thoracic Surgery Hokkaido University Sapporo JapanAbstract Background Lung adenocarcinomas with micropapillary pattern (MP) or solid pattern (SP) have poor prognosis with frequent postoperative recurrence. However, treatment strategies for these histological subtypes have not been established. This study examined the recurrence rates and patterns in patients with these histological subtypes. Methods Overall, 238 patients with lung adenocarcinoma who underwent radical resection were included. According to the histological subtypes, the patients were classified into three groups: neither MP nor SP (MP−/SP−), MP (MP+), and SP (SP+). The clinical and pathological characteristics and recurrence‐free survival (RFS) were examined in each group. In addition, univariate and multivariate analyses were performed to investigate the recurrence factors. The site of recurrence, PD‐L1 expression, and driver mutations were examined in patients with postoperative recurrence. Results The recurrence rates were significantly higher in the MP+ and SP+ groups (p = 0.01). The RFS was significantly shorter in the MP+ and SP+ groups (p < 0.001) than in the MP−/SP− group, especially in pStage 1A (p = 0.001). The relationship between recurrence and pathologic factors was significant for pleural, lymphatic, and vascular invasion, as well as MP in univariate analysis and only for MP in multivariate analysis. Most recurrences were distant metastases in the MP+ and SP+ groups. PD‐L1 was highly expressed in recurrent SP+ cases. Conclusions Early‐stage lung adenocarcinoma with MP or SP frequently has postoperative recurrence. Prevention of distant metastases is important in these patients to improve prognosis, and aggressive postoperative chemotherapy may be considered.https://doi.org/10.1111/1759-7714.15087lung adenocarcinomamicropapillary patternsolid pattern |
| spellingShingle | Naoki Takeno Shintaro Tarumi Masahiro Abe Yasuhiro Suzuki Ichiro Kinoshita Tatsuya Kato Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends Thoracic Cancer lung adenocarcinoma micropapillary pattern solid pattern |
| title | Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends |
| title_full | Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends |
| title_fullStr | Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends |
| title_full_unstemmed | Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends |
| title_short | Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends |
| title_sort | lung adenocarcinoma with micropapillary and solid patterns recurrence rate and trends |
| topic | lung adenocarcinoma micropapillary pattern solid pattern |
| url | https://doi.org/10.1111/1759-7714.15087 |
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