Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a small pore, hexameric structure. However, these chann...

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Bibliographic Details
Main Authors: Hirohide Takahashi, Toshiki Yamada, Jerod S Denton, Kevin Strange, Erkan Karakas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
cryo-EM
VRAC
LRRC8C
LRRC8A
chimera
ion channel
Online Access:https://elifesciences.org/articles/82431

Internet

https://elifesciences.org/articles/82431

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