The miRNA-21-5p Payload in Exosomes from M2 Macrophages Drives Tumor Cell Aggression via PTEN/Akt Signaling in Renal Cell Carcinoma

The miRNA-21-5p Payload in Exosomes from M2 Macrophages Drives Tumor Cell Aggression via PTEN/Akt Signaling in Renal Cell Carcinoma

M2 macrophages in the tumor microenvironment are important drivers of cancer metastasis. Exosomes play a critical role in the crosstalk between different cells by delivering microRNAs or other cargos. Whether exosomes derived from pro-tumorigenic M2 macrophages (M2-Exos) could modulate the metastati...

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Bibliographic Details
Main Authors: Zhicheng Zhang, Junhui Hu, Moe Ishihara, Allison C. Sharrow, Kailey Flora, Yao He, Lily Wu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
miRNA-21-5p
exosomes
M2 macrophages
renal cell carcinoma
invasion
migration
Online Access:https://www.mdpi.com/1422-0067/23/6/3005

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