Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature
This paper reviews our institutional experience in the management of rhino-facial entomophthoromycosis, a rare subcutaneous fungal infection. We adopt a fixed two-phase protocol comprising an initial ‘intensive phase’ (two-drug regimen) followed by an ‘eradication phase’ (monotherapy). We present fi...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2022-11-01
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| Series: | Oman Medical Journal |
| Subjects: | |
| Online Access: | https://omjournal.org/articleDetails.aspx?coType=1&aId=3272 |
| _version_ | 1811180111193440256 |
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| author | Srinivas Chadaram Preetam Chappity Vinaykumar Hallur Prity Sharma Pradhan Pradeep Pradipta Parida |
| author_facet | Srinivas Chadaram Preetam Chappity Vinaykumar Hallur Prity Sharma Pradhan Pradeep Pradipta Parida |
| author_sort | Srinivas Chadaram |
| collection | DOAJ |
| description | This paper reviews our institutional experience in the management of rhino-facial entomophthoromycosis, a rare subcutaneous fungal infection. We adopt a fixed two-phase protocol comprising an initial ‘intensive phase’ (two-drug regimen) followed by an ‘eradication phase’ (monotherapy). We present five patients treated between May 2013 and May 2020 in our institution who were subjected to the mentioned protocol. All five patients received six months of supersaturated potassium iodide solution and itraconazole, followed by four months of monotherapy with only supersaturated potassium iodide solution. All patients responded well to the treatment and were disease-free on follow-up of a minimum two years post-treatment. We recommend this procedure for all typical cases of entomophthoromycosis and suggest avoiding surgical intervention which may disseminate the fungus and delay response to treatment. |
| first_indexed | 2024-04-11T06:44:48Z |
| format | Article |
| id | doaj.art-aa8349d07acb4e1ba5fb73a2ad3ed118 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-04-11T06:44:48Z |
| publishDate | 2022-11-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-aa8349d07acb4e1ba5fb73a2ad3ed1182022-12-22T04:39:22ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042022-11-01376e448e44810.5001/omj.2022.29Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of LiteratureSrinivas Chadaram0Preetam Chappity1Vinaykumar Hallur2Prity Sharma3Pradhan Pradeep4Pradipta Parida5Ear, Nose, and Throat Department, All India Institute of Medical Sciences, Bhubaneswar, IndiaEar, Nose, and Throat Department, All India Institute of Medical Sciences, Bhubaneswar, IndiaMicrobiology Department, All India Institute of Medical Sciences, Bhubaneswar, IndiaEar, Nose, and Throat Department, All India Institute of Medical Sciences, Bhubaneswar, IndiaEar, Nose, and Throat Department, All India Institute of Medical Sciences, Bhubaneswar, IndiaEar, Nose, and Throat Department, All India Institute of Medical Sciences, Bhubaneswar, IndiaThis paper reviews our institutional experience in the management of rhino-facial entomophthoromycosis, a rare subcutaneous fungal infection. We adopt a fixed two-phase protocol comprising an initial ‘intensive phase’ (two-drug regimen) followed by an ‘eradication phase’ (monotherapy). We present five patients treated between May 2013 and May 2020 in our institution who were subjected to the mentioned protocol. All five patients received six months of supersaturated potassium iodide solution and itraconazole, followed by four months of monotherapy with only supersaturated potassium iodide solution. All patients responded well to the treatment and were disease-free on follow-up of a minimum two years post-treatment. We recommend this procedure for all typical cases of entomophthoromycosis and suggest avoiding surgical intervention which may disseminate the fungus and delay response to treatment.https://omjournal.org/articleDetails.aspx?coType=1&aId=3272entomophthoromycosisskinzygomycosisbasidiobolomycosispotassium iodideazolesindia |
| spellingShingle | Srinivas Chadaram Preetam Chappity Vinaykumar Hallur Prity Sharma Pradhan Pradeep Pradipta Parida Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature Oman Medical Journal entomophthoromycosis skin zygomycosis basidiobolomycosis potassium iodide azoles india |
| title | Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature |
| title_full | Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature |
| title_fullStr | Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature |
| title_full_unstemmed | Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature |
| title_short | Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature |
| title_sort | efficacy of two phase treatment regimen for rhino facial entomophthoromycosis our experience and review of literature |
| topic | entomophthoromycosis skin zygomycosis basidiobolomycosis potassium iodide azoles india |
| url | https://omjournal.org/articleDetails.aspx?coType=1&aId=3272 |
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