Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis
Atherosclerosis is one of the most important medical and social problems of modern society. Atherosclerosis causes a large number of hospitalizations, disability, and mortality. A considerable amount of evidence suggests that inflammation is one of the key links in the pathogenesis of atherosclerosi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/8/1474 |
| _version_ | 1797410041998868480 |
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| author | Stanislav Kotlyarov |
| author_facet | Stanislav Kotlyarov |
| author_sort | Stanislav Kotlyarov |
| collection | DOAJ |
| description | Atherosclerosis is one of the most important medical and social problems of modern society. Atherosclerosis causes a large number of hospitalizations, disability, and mortality. A considerable amount of evidence suggests that inflammation is one of the key links in the pathogenesis of atherosclerosis. Inflammation in the vascular wall has extensive cross-linkages with lipid metabolism, and lipid mediators act as a central link in the regulation of inflammation in the vascular wall. Data on the role of genetics and epigenetic factors in the development of atherosclerosis are of great interest. A growing body of evidence is strengthening the understanding of the significance of gene polymorphism, as well as gene expression dysregulation involved in cross-links between lipid metabolism and the innate immune system. A better understanding of the genetic basis and molecular mechanisms of disease pathogenesis is an important step towards solving the problems of its early diagnosis and treatment. |
| first_indexed | 2024-03-09T04:24:09Z |
| format | Article |
| id | doaj.art-aa83620fdcc24e46a7d41277cda018c4 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T04:24:09Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-aa83620fdcc24e46a7d41277cda018c42023-12-03T13:43:22ZengMDPI AGGenes2073-44252022-08-01138147410.3390/genes13081474Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in AtherogenesisStanislav Kotlyarov0Department of Nursing, Ryazan State Medical University, 390026 Ryazan, RussiaAtherosclerosis is one of the most important medical and social problems of modern society. Atherosclerosis causes a large number of hospitalizations, disability, and mortality. A considerable amount of evidence suggests that inflammation is one of the key links in the pathogenesis of atherosclerosis. Inflammation in the vascular wall has extensive cross-linkages with lipid metabolism, and lipid mediators act as a central link in the regulation of inflammation in the vascular wall. Data on the role of genetics and epigenetic factors in the development of atherosclerosis are of great interest. A growing body of evidence is strengthening the understanding of the significance of gene polymorphism, as well as gene expression dysregulation involved in cross-links between lipid metabolism and the innate immune system. A better understanding of the genetic basis and molecular mechanisms of disease pathogenesis is an important step towards solving the problems of its early diagnosis and treatment.https://www.mdpi.com/2073-4425/13/8/1474atherosclerosisgenespolymorphismepigeneticsmicroRNAlncRNAs |
| spellingShingle | Stanislav Kotlyarov Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis Genes atherosclerosis genes polymorphism epigenetics microRNA lncRNAs |
| title | Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis |
| title_full | Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis |
| title_fullStr | Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis |
| title_full_unstemmed | Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis |
| title_short | Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis |
| title_sort | genetic and epigenetic regulation of lipoxygenase pathways and reverse cholesterol transport in atherogenesis |
| topic | atherosclerosis genes polymorphism epigenetics microRNA lncRNAs |
| url | https://www.mdpi.com/2073-4425/13/8/1474 |
| work_keys_str_mv | AT stanislavkotlyarov geneticandepigeneticregulationoflipoxygenasepathwaysandreversecholesteroltransportinatherogenesis |