Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment
Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and microribonucleic acids (miRNAs) organelles and play important rol...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2018-12-01
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| Series: | Folia Veterinaria |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/fv-2018-0033 |
| _version_ | 1818730990118371328 |
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| author | Huňáková K. Hluchý M. Kuricová M. Ševčík K. Rosocha J. Ledecký V. |
| author_facet | Huňáková K. Hluchý M. Kuricová M. Ševčík K. Rosocha J. Ledecký V. |
| author_sort | Huňáková K. |
| collection | DOAJ |
| description | Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and microribonucleic acids (miRNAs) organelles and play important roles in intercellular communication and the regulation of tissue regeneration. This transfer of bioactive molecules plays a main role in: tumor invasion and metastasis, immune and inflammation modulation, epithelial-mesenchymal transition and neurobiology. Mesenchymal Stem Cells (MSC) exosomes provide new perspectives for the development of an off-the-shelf and cell-free MSC therapy for the treatment of cartilage injuries and osteoarthritis. This report describes the progress in exosome studies and potential clinical use for osteoarthritis treatment. |
| first_indexed | 2024-12-17T23:10:33Z |
| format | Article |
| id | doaj.art-aa83823dd2794f239371c8badfc68f68 |
| institution | Directory Open Access Journal |
| issn | 2453-7837 |
| language | English |
| last_indexed | 2024-12-17T23:10:33Z |
| publishDate | 2018-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Folia Veterinaria |
| spelling | doaj.art-aa83823dd2794f239371c8badfc68f682022-12-21T21:29:08ZengSciendoFolia Veterinaria2453-78372018-12-01624192310.2478/fv-2018-0033fv-2018-0033Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis TreatmentHuňáková K.0Hluchý M.1Kuricová M.2Ševčík K.3Rosocha J.4Ledecký V.5Small Animal Clinic, University of Veterinary Medicine and Pharmacy Komenského 73, 041 81KošiceSmall Animal Clinic, University of Veterinary Medicine and Pharmacy Komenského 73, 041 81KošiceSmall Animal Clinic, University of Veterinary Medicine and Pharmacy Komenského 73, 041 81KošiceSmall Animal Clinic, University of Veterinary Medicine and Pharmacy Komenského 73, 041 81KošiceAssociated Tissue Bank, Faculty of Medicine of P. J. Šafárik University and University Hospital of L. Pasteur, KošiceSlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy Komenského 73, 041 81KošiceExosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and microribonucleic acids (miRNAs) organelles and play important roles in intercellular communication and the regulation of tissue regeneration. This transfer of bioactive molecules plays a main role in: tumor invasion and metastasis, immune and inflammation modulation, epithelial-mesenchymal transition and neurobiology. Mesenchymal Stem Cells (MSC) exosomes provide new perspectives for the development of an off-the-shelf and cell-free MSC therapy for the treatment of cartilage injuries and osteoarthritis. This report describes the progress in exosome studies and potential clinical use for osteoarthritis treatment.https://doi.org/10.2478/fv-2018-0033exosomesosteoarthritisstem celltreatment |
| spellingShingle | Huňáková K. Hluchý M. Kuricová M. Ševčík K. Rosocha J. Ledecký V. Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment Folia Veterinaria exosomes osteoarthritis stem cell treatment |
| title | Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment |
| title_full | Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment |
| title_fullStr | Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment |
| title_full_unstemmed | Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment |
| title_short | Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment |
| title_sort | role of mesenchymal stem cells derived exosomes in osteoarthritis treatment |
| topic | exosomes osteoarthritis stem cell treatment |
| url | https://doi.org/10.2478/fv-2018-0033 |
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