The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
Abstract Cancer stem cells (CSCs), a subpopulation of cancer cells with ability of initiating tumorigenesis, exist in many kinds of tumors including breast cancer. Cancer stem cells contribute to treatment resistance and relapse. Conventional treatments only kill differentiated cancer cells, but spa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2015-09-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-015-0199-4 |
| _version_ | 1797763164300902400 |
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| author | Zhiju Zhao Shu Li Erwei Song Suling Liu |
| author_facet | Zhiju Zhao Shu Li Erwei Song Suling Liu |
| author_sort | Zhiju Zhao |
| collection | DOAJ |
| description | Abstract Cancer stem cells (CSCs), a subpopulation of cancer cells with ability of initiating tumorigenesis, exist in many kinds of tumors including breast cancer. Cancer stem cells contribute to treatment resistance and relapse. Conventional treatments only kill differentiated cancer cells, but spare CSCs. Combining conventional treatments with therapeutic drugs targeting to CSCs will eradicate cancer cells more efficiently. Studying the molecular mechanisms of CSCs regulation is essential for developing new therapeutic strategies. Growing evidences showed CSCs are regulated by non-coding RNA (ncRNA) including microRNAs and long non-coding RNAs (lncRNAs), and histone-modifiers, such as let-7, miR-93, miR-100, HOTAIR, Bmi-1 and EZH2. Herein we review the roles of microRNAs, lncRNAs and histone-modifiers especially Polycomb family proteins in regulating breast cancer stem cells (BCSCs). |
| first_indexed | 2024-03-12T19:38:38Z |
| format | Article |
| id | doaj.art-aa843fbf53e54d0bb12cdc86526fa47f |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T19:38:38Z |
| publishDate | 2015-09-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-aa843fbf53e54d0bb12cdc86526fa47f2023-08-02T04:02:37ZengOxford University PressProtein & Cell1674-800X1674-80182015-09-0172899910.1007/s13238-015-0199-4The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cellsZhiju Zhao0Shu Li1Erwei Song2Suling Liu3Innovation Center for Cell Signalling and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of ChinaDepartment of Pathophysiology, Wannan Medical CollegeDepartment of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-Sen UniversityInnovation Center for Cell Signalling and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of ChinaAbstract Cancer stem cells (CSCs), a subpopulation of cancer cells with ability of initiating tumorigenesis, exist in many kinds of tumors including breast cancer. Cancer stem cells contribute to treatment resistance and relapse. Conventional treatments only kill differentiated cancer cells, but spare CSCs. Combining conventional treatments with therapeutic drugs targeting to CSCs will eradicate cancer cells more efficiently. Studying the molecular mechanisms of CSCs regulation is essential for developing new therapeutic strategies. Growing evidences showed CSCs are regulated by non-coding RNA (ncRNA) including microRNAs and long non-coding RNAs (lncRNAs), and histone-modifiers, such as let-7, miR-93, miR-100, HOTAIR, Bmi-1 and EZH2. Herein we review the roles of microRNAs, lncRNAs and histone-modifiers especially Polycomb family proteins in regulating breast cancer stem cells (BCSCs).http://link.springer.com/article/10.1007/s13238-015-0199-4breast cancer stem cellsmicroRNAlncRNAhistone-modifierPolycomb group proteins |
| spellingShingle | Zhiju Zhao Shu Li Erwei Song Suling Liu The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells Protein & Cell breast cancer stem cells microRNA lncRNA histone-modifier Polycomb group proteins |
| title | The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells |
| title_full | The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells |
| title_fullStr | The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells |
| title_full_unstemmed | The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells |
| title_short | The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells |
| title_sort | roles of ncrnas and histone modifiers in regulating breast cancer stem cells |
| topic | breast cancer stem cells microRNA lncRNA histone-modifier Polycomb group proteins |
| url | http://link.springer.com/article/10.1007/s13238-015-0199-4 |
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