Exploring the association between microbiota and behaviour in suckling piglets
Abstract It is increasingly recognised that the microbes residing in the gastrointestinal tract can influence brain physiology and behaviour, via the microbiota–gut–brain axis. Here, we made a first explorative evaluation at the association between the gut microbiota and behaviour in suckling piglet...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16259-3 |
| _version_ | 1818510039222059008 |
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| author | R. Choudhury A. Middelkoop J. E. Bolhuis M. Kleerebezem |
| author_facet | R. Choudhury A. Middelkoop J. E. Bolhuis M. Kleerebezem |
| author_sort | R. Choudhury |
| collection | DOAJ |
| description | Abstract It is increasingly recognised that the microbes residing in the gastrointestinal tract can influence brain physiology and behaviour, via the microbiota–gut–brain axis. Here, we made a first explorative evaluation at the association between the gut microbiota and behaviour in suckling piglets. 16S microbiota profiling information was obtained from two independent replicate experiments at 2 and 4 weeks of age. Piglets underwent a backtest to assess their personality or coping style at 2 weeks of age, and were subjected to a combined open field and novel object test at 3.5 weeks of age, recording anxiety-related and exploratory behaviour. The number of squeals vocalised during the open field test was associated with microbial groups such as Coprococcus 3 and CAG-873, whereas in the novel object test, explorative behaviour was significantly associated with microbial genera like Atopobium and Prevotella. Overall, this study explores the microbiota-behavioural relation by employing multivariate analysis and exemplifies the importance of individualised analyses when evaluating such relationships. |
| first_indexed | 2024-12-10T22:53:45Z |
| format | Article |
| id | doaj.art-aa8528f2eaa8413fbfa15973ca6576bd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-10T22:53:45Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-aa8528f2eaa8413fbfa15973ca6576bd2022-12-22T01:30:20ZengNature PortfolioScientific Reports2045-23222022-07-011211910.1038/s41598-022-16259-3Exploring the association between microbiota and behaviour in suckling pigletsR. Choudhury0A. Middelkoop1J. E. Bolhuis2M. Kleerebezem3Host-Microbe Interactomics Group, Department of Animal Sciences, Wageningen University & ResearchAdaptation Physiology Group, Department of Animal Sciences, Wageningen University & ResearchAdaptation Physiology Group, Department of Animal Sciences, Wageningen University & ResearchHost-Microbe Interactomics Group, Department of Animal Sciences, Wageningen University & ResearchAbstract It is increasingly recognised that the microbes residing in the gastrointestinal tract can influence brain physiology and behaviour, via the microbiota–gut–brain axis. Here, we made a first explorative evaluation at the association between the gut microbiota and behaviour in suckling piglets. 16S microbiota profiling information was obtained from two independent replicate experiments at 2 and 4 weeks of age. Piglets underwent a backtest to assess their personality or coping style at 2 weeks of age, and were subjected to a combined open field and novel object test at 3.5 weeks of age, recording anxiety-related and exploratory behaviour. The number of squeals vocalised during the open field test was associated with microbial groups such as Coprococcus 3 and CAG-873, whereas in the novel object test, explorative behaviour was significantly associated with microbial genera like Atopobium and Prevotella. Overall, this study explores the microbiota-behavioural relation by employing multivariate analysis and exemplifies the importance of individualised analyses when evaluating such relationships.https://doi.org/10.1038/s41598-022-16259-3 |
| spellingShingle | R. Choudhury A. Middelkoop J. E. Bolhuis M. Kleerebezem Exploring the association between microbiota and behaviour in suckling piglets Scientific Reports |
| title | Exploring the association between microbiota and behaviour in suckling piglets |
| title_full | Exploring the association between microbiota and behaviour in suckling piglets |
| title_fullStr | Exploring the association between microbiota and behaviour in suckling piglets |
| title_full_unstemmed | Exploring the association between microbiota and behaviour in suckling piglets |
| title_short | Exploring the association between microbiota and behaviour in suckling piglets |
| title_sort | exploring the association between microbiota and behaviour in suckling piglets |
| url | https://doi.org/10.1038/s41598-022-16259-3 |
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