The regulatory role and mechanism of exosomes in hepatic fibrosis
Globally, the prevalence and fatality rates of liver disorders are on the rise. Among chronic liver conditions, hepatic fibrosis stands out as a central pathological process. Despite this, approved treatments for hepatic fibrosis are currently lacking. Exosomes, small extracellular vesicles secreted...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1284742/full |
| _version_ | 1797435062724067328 |
|---|---|
| author | Youli Yao Da Chen Zengchang Yue |
| author_facet | Youli Yao Da Chen Zengchang Yue |
| author_sort | Youli Yao |
| collection | DOAJ |
| description | Globally, the prevalence and fatality rates of liver disorders are on the rise. Among chronic liver conditions, hepatic fibrosis stands out as a central pathological process. Despite this, approved treatments for hepatic fibrosis are currently lacking. Exosomes, small extracellular vesicles secreted by various cell types, play a significant role in intercellular communication and have emerged as essential mediators in liver fibrosis. In this regard, this review compiles the mechanisms through which exosomes regulate hepatic fibrosis, encompassing diverse targets and signaling pathways. Furthermore, it delves into the regulatory impact of exosomes modulated by natural plant-derived, endogenous, and synthetic compounds as potential therapeutic strategies for addressing hepatic fibrosis. |
| first_indexed | 2024-03-09T10:41:49Z |
| format | Article |
| id | doaj.art-aa85ed10f4dd41b1b2469702513f1df0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T10:41:49Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-aa85ed10f4dd41b1b2469702513f1df02023-12-01T13:43:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.12847421284742The regulatory role and mechanism of exosomes in hepatic fibrosisYouli Yao0Da Chen1Zengchang Yue2College of Electronics and Information Engineering, Shandong University of Science and Technology, Qingdao, ChinaCollege of Electronics and Information Engineering, Shandong University of Science and Technology, Qingdao, ChinaDepartment of Neurology, Mindong Hospital Affiliated to Fujian Medical University, Ningde, ChinaGlobally, the prevalence and fatality rates of liver disorders are on the rise. Among chronic liver conditions, hepatic fibrosis stands out as a central pathological process. Despite this, approved treatments for hepatic fibrosis are currently lacking. Exosomes, small extracellular vesicles secreted by various cell types, play a significant role in intercellular communication and have emerged as essential mediators in liver fibrosis. In this regard, this review compiles the mechanisms through which exosomes regulate hepatic fibrosis, encompassing diverse targets and signaling pathways. Furthermore, it delves into the regulatory impact of exosomes modulated by natural plant-derived, endogenous, and synthetic compounds as potential therapeutic strategies for addressing hepatic fibrosis.https://www.frontiersin.org/articles/10.3389/fphar.2023.1284742/fullexosomeshepatic fibrosissignaling pathwayshepatic stellate cellstherapy targets |
| spellingShingle | Youli Yao Da Chen Zengchang Yue The regulatory role and mechanism of exosomes in hepatic fibrosis Frontiers in Pharmacology exosomes hepatic fibrosis signaling pathways hepatic stellate cells therapy targets |
| title | The regulatory role and mechanism of exosomes in hepatic fibrosis |
| title_full | The regulatory role and mechanism of exosomes in hepatic fibrosis |
| title_fullStr | The regulatory role and mechanism of exosomes in hepatic fibrosis |
| title_full_unstemmed | The regulatory role and mechanism of exosomes in hepatic fibrosis |
| title_short | The regulatory role and mechanism of exosomes in hepatic fibrosis |
| title_sort | regulatory role and mechanism of exosomes in hepatic fibrosis |
| topic | exosomes hepatic fibrosis signaling pathways hepatic stellate cells therapy targets |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1284742/full |
| work_keys_str_mv | AT youliyao theregulatoryroleandmechanismofexosomesinhepaticfibrosis AT dachen theregulatoryroleandmechanismofexosomesinhepaticfibrosis AT zengchangyue theregulatoryroleandmechanismofexosomesinhepaticfibrosis AT youliyao regulatoryroleandmechanismofexosomesinhepaticfibrosis AT dachen regulatoryroleandmechanismofexosomesinhepaticfibrosis AT zengchangyue regulatoryroleandmechanismofexosomesinhepaticfibrosis |