Behavioral investigation of mice with experimental autoimmune encephalomyelitis
Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2011-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700018&lng=en&tlng=en |
| _version_ | 1818259350467117056 |
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| author | David Henrique Rodrigues Márcia de Carvalho Vilela Norinne Lacerda-Queiroz Aline Silva de Miranda Larissa Fonseca da Cunha Sousa Helton José dos Reis Antônio Lúcio Teixeira |
| author_facet | David Henrique Rodrigues Márcia de Carvalho Vilela Norinne Lacerda-Queiroz Aline Silva de Miranda Larissa Fonseca da Cunha Sousa Helton José dos Reis Antônio Lúcio Teixeira |
| author_sort | David Henrique Rodrigues |
| collection | DOAJ |
| description | Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG35-55 model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG35-55 are probably subtle or absent. |
| first_indexed | 2024-12-12T18:14:03Z |
| format | Article |
| id | doaj.art-aa86066b3b364679b872adfd45644f46 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-12T18:14:03Z |
| publishDate | 2011-12-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-aa86066b3b364679b872adfd45644f462022-12-22T00:16:19ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272011-12-0169693894210.1590/S0004-282X2011000700018S0004-282X2011000700018Behavioral investigation of mice with experimental autoimmune encephalomyelitisDavid Henrique Rodrigues0Márcia de Carvalho Vilela1Norinne Lacerda-Queiroz2Aline Silva de Miranda3Larissa Fonseca da Cunha Sousa4Helton José dos Reis5Antônio Lúcio Teixeira6Universidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisMultiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG35-55 model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG35-55 are probably subtle or absent.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700018&lng=en&tlng=enesclerose múltiplaencefalomielite autoimune experimentalcompor-tamentomemóriaansiedade |
| spellingShingle | David Henrique Rodrigues Márcia de Carvalho Vilela Norinne Lacerda-Queiroz Aline Silva de Miranda Larissa Fonseca da Cunha Sousa Helton José dos Reis Antônio Lúcio Teixeira Behavioral investigation of mice with experimental autoimmune encephalomyelitis Arquivos de Neuro-Psiquiatria esclerose múltipla encefalomielite autoimune experimental compor-tamento memória ansiedade |
| title | Behavioral investigation of mice with experimental autoimmune encephalomyelitis |
| title_full | Behavioral investigation of mice with experimental autoimmune encephalomyelitis |
| title_fullStr | Behavioral investigation of mice with experimental autoimmune encephalomyelitis |
| title_full_unstemmed | Behavioral investigation of mice with experimental autoimmune encephalomyelitis |
| title_short | Behavioral investigation of mice with experimental autoimmune encephalomyelitis |
| title_sort | behavioral investigation of mice with experimental autoimmune encephalomyelitis |
| topic | esclerose múltipla encefalomielite autoimune experimental compor-tamento memória ansiedade |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700018&lng=en&tlng=en |
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