Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials
Oral candidiasis is the most common opportunistic fungal infection caused by commensal <i>Candida</i> species. Since there are various local and systemic predisposing factors for the disease, the treatment also varies from topical to systemic antifungal agents. Nystatin is a common antif...
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MDPI AG
2022-10-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1677 |
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| author | Anamika Rai Satya Ranjan Misra Saurav Panda Grzegorz Sokolowski Lora Mishra Rupsa Das Barbara Lapinska |
| author_facet | Anamika Rai Satya Ranjan Misra Saurav Panda Grzegorz Sokolowski Lora Mishra Rupsa Das Barbara Lapinska |
| author_sort | Anamika Rai |
| collection | DOAJ |
| description | Oral candidiasis is the most common opportunistic fungal infection caused by commensal <i>Candida</i> species. Since there are various local and systemic predisposing factors for the disease, the treatment also varies from topical to systemic antifungal agents. Nystatin is a common antifungal agent used topically. The aim of this systematic review was to evaluate and compare the efficacy of different antifungal agents and the safety of nystatin in the treatment of oral candidiasis. Three electronic databases were searched for randomized controlled trials comparing nystatin with other anti-fungal therapies or placebo. Clinical and/or mycological cure was the outcome evaluation. A meta-analysis and descriptive study on the efficacy, treatment protocols, and safety of nystatin was also conducted. The meta-analysis included five studies, which compared the efficacy of nystatin suspensions with photodynamic therapy. A significant difference in the colony-forming units per milliliters (CFU/mL) of <i>Candida</i> species was observed at 60 days intervals for both palatal mucosa and denture surfaces, with both groups favoring nystatin with low heterogeneity at a 95% confidence interval. Nystatin and photodynamic therapy were found to be equally effective for the clinical remission of denture stomatitis as well as a significant reduction of CFU/mL of <i>Candida</i> species from dentures and palatal surfaces of the patients. |
| first_indexed | 2024-03-09T18:56:01Z |
| format | Article |
| id | doaj.art-aa86326e7c204c158e5c9ce2dd5faf45 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:56:01Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-aa86326e7c204c158e5c9ce2dd5faf452023-11-24T05:29:09ZengMDPI AGLife2075-17292022-10-011211167710.3390/life12111677Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical TrialsAnamika Rai0Satya Ranjan Misra1Saurav Panda2Grzegorz Sokolowski3Lora Mishra4Rupsa Das5Barbara Lapinska6Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, IndiaDepartment of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, IndiaDepartment of Periodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, IndiaDepartment of Prosthetics, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, PolandDepartment of Conservative Dentistry & Endodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, IndiaDepartment of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, IndiaDepartment of General Dentistry, Medical University of Lodz, 251 Pomorska St, 92-213 Lodz, PolandOral candidiasis is the most common opportunistic fungal infection caused by commensal <i>Candida</i> species. Since there are various local and systemic predisposing factors for the disease, the treatment also varies from topical to systemic antifungal agents. Nystatin is a common antifungal agent used topically. The aim of this systematic review was to evaluate and compare the efficacy of different antifungal agents and the safety of nystatin in the treatment of oral candidiasis. Three electronic databases were searched for randomized controlled trials comparing nystatin with other anti-fungal therapies or placebo. Clinical and/or mycological cure was the outcome evaluation. A meta-analysis and descriptive study on the efficacy, treatment protocols, and safety of nystatin was also conducted. The meta-analysis included five studies, which compared the efficacy of nystatin suspensions with photodynamic therapy. A significant difference in the colony-forming units per milliliters (CFU/mL) of <i>Candida</i> species was observed at 60 days intervals for both palatal mucosa and denture surfaces, with both groups favoring nystatin with low heterogeneity at a 95% confidence interval. Nystatin and photodynamic therapy were found to be equally effective for the clinical remission of denture stomatitis as well as a significant reduction of CFU/mL of <i>Candida</i> species from dentures and palatal surfaces of the patients.https://www.mdpi.com/2075-1729/12/11/1677nystatinoral candidiasisdenture stomatitissystematic reviewmeta-analysisphotodynamic therapy |
| spellingShingle | Anamika Rai Satya Ranjan Misra Saurav Panda Grzegorz Sokolowski Lora Mishra Rupsa Das Barbara Lapinska Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials Life nystatin oral candidiasis denture stomatitis systematic review meta-analysis photodynamic therapy |
| title | Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials |
| title_full | Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials |
| title_fullStr | Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials |
| title_full_unstemmed | Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials |
| title_short | Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials |
| title_sort | nystatin effectiveness in oral candidiasis treatment a systematic review meta analysis of clinical trials |
| topic | nystatin oral candidiasis denture stomatitis systematic review meta-analysis photodynamic therapy |
| url | https://www.mdpi.com/2075-1729/12/11/1677 |
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