Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin
Three novel face creams containing dexpanthenol with different lipid contents were developed for dry skin sufferers: a day face cream (DFC), a day face cream with sun protection (DFC-SPF), and a night face cream (NFC). Three identically designed studies (N = 42–44 each) were conducted with healthy a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/8/4/93 |
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| author | Ana Barrionuevo-Gonzalez Sonja Trapp Raffaella de Salvo Marina Reitmann Eva Cassar Siham Rharbaoui Florence Reber Hans Stettler |
| author_facet | Ana Barrionuevo-Gonzalez Sonja Trapp Raffaella de Salvo Marina Reitmann Eva Cassar Siham Rharbaoui Florence Reber Hans Stettler |
| author_sort | Ana Barrionuevo-Gonzalez |
| collection | DOAJ |
| description | Three novel face creams containing dexpanthenol with different lipid contents were developed for dry skin sufferers: a day face cream (DFC), a day face cream with sun protection (DFC-SPF), and a night face cream (NFC). Three identically designed studies (N = 42–44 each) were conducted with healthy adults of three ethnicities (African, Asian, Caucasian) with dry/sensitive skin. Effects on stratum corneum (SC) hydration, SC lipid content, and skin elasticity were quantified by established noninvasive methods during the 4-week studies. After single and repeated once-daily applications of the face creams, facial hydration significantly increased from baseline. On day 28, the mean increments in skin hydration amounted to 27%, 26%, and 27% (<i>p</i> < 0.0001 each) for DFC, DFC-SPF, and NFC, respectively. Favorable effects of DFC, DFC-SPF, and NFC on facial moisturization were observed in all three ethnic groups. The enhancements in SC hydration were not paralleled by improvements in skin elasticity parameters but lipid analyses showed significant increases in SC cholesterol, SC free fatty acid, and/or SC ceramide levels. All three face creams were well tolerated and achieved a high product satisfaction and acceptability by study participants. Our findings support the once-daily use of the face creams in adults of different ethnicities with dry and sensitive skin. |
| first_indexed | 2024-03-10T04:22:10Z |
| format | Article |
| id | doaj.art-aa86d7f72f3742e0b9b4cf4f16173629 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-10T04:22:10Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-aa86d7f72f3742e0b9b4cf4f161736292023-11-23T07:47:11ZengMDPI AGCosmetics2079-92842021-09-01849310.3390/cosmetics8040093Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive SkinAna Barrionuevo-Gonzalez0Sonja Trapp1Raffaella de Salvo2Marina Reitmann3Eva Cassar4Siham Rharbaoui5Florence Reber6Hans Stettler7Bayer Hispania, S.L., 08970 Sant Joan Despí, SpainBayer Consumer Care AG, 4002 Basel, SwitzerlandBayer Consumer Care AG, 4002 Basel, SwitzerlandExcelya Germany GmbH, 79108 Freiburg, GermanyNewtone Technologies, 69006 Lyon, FranceEurofins Dermscan/Pharmascan, 69100 Villeurbanne, FranceEurofins Dermscan/Pharmascan, 69100 Villeurbanne, FranceBayer Consumer Care AG, 4002 Basel, SwitzerlandThree novel face creams containing dexpanthenol with different lipid contents were developed for dry skin sufferers: a day face cream (DFC), a day face cream with sun protection (DFC-SPF), and a night face cream (NFC). Three identically designed studies (N = 42–44 each) were conducted with healthy adults of three ethnicities (African, Asian, Caucasian) with dry/sensitive skin. Effects on stratum corneum (SC) hydration, SC lipid content, and skin elasticity were quantified by established noninvasive methods during the 4-week studies. After single and repeated once-daily applications of the face creams, facial hydration significantly increased from baseline. On day 28, the mean increments in skin hydration amounted to 27%, 26%, and 27% (<i>p</i> < 0.0001 each) for DFC, DFC-SPF, and NFC, respectively. Favorable effects of DFC, DFC-SPF, and NFC on facial moisturization were observed in all three ethnic groups. The enhancements in SC hydration were not paralleled by improvements in skin elasticity parameters but lipid analyses showed significant increases in SC cholesterol, SC free fatty acid, and/or SC ceramide levels. All three face creams were well tolerated and achieved a high product satisfaction and acceptability by study participants. Our findings support the once-daily use of the face creams in adults of different ethnicities with dry and sensitive skin.https://www.mdpi.com/2079-9284/8/4/93dexpanthenoldry skinethnicityface creammoisturizationstudy |
| spellingShingle | Ana Barrionuevo-Gonzalez Sonja Trapp Raffaella de Salvo Marina Reitmann Eva Cassar Siham Rharbaoui Florence Reber Hans Stettler Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin Cosmetics dexpanthenol dry skin ethnicity face cream moisturization study |
| title | Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin |
| title_full | Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin |
| title_fullStr | Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin |
| title_full_unstemmed | Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin |
| title_short | Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin |
| title_sort | three new dexpanthenol containing face creams performance and acceptability after single and repeated applications in subjects of different ethnicity with dry and sensitive skin |
| topic | dexpanthenol dry skin ethnicity face cream moisturization study |
| url | https://www.mdpi.com/2079-9284/8/4/93 |
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