Current trends of genetics in apical periodontitis research
Abstract: Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidat...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pesquisa Odontológica
2018-10-01
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| Series: | Brazilian Oral Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500607&lng=en&tlng=en |
| _version_ | 1818391199275286528 |
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| author | Erika Calvano Küchler Jardel Francisco Mazzi-Chaves Leonardo Santos Antunes Christian Kirschneck Flares Baratto-Filho Manoel Damião Sousa-Neto |
| author_facet | Erika Calvano Küchler Jardel Francisco Mazzi-Chaves Leonardo Santos Antunes Christian Kirschneck Flares Baratto-Filho Manoel Damião Sousa-Neto |
| author_sort | Erika Calvano Küchler |
| collection | DOAJ |
| description | Abstract: Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidate genes and AP. Some studies have been conducted on knockout mice with a deficiency in certain proteins, leading to more or less severe AP, and thus suggesting a pivotal role of these genes in AP pathogenesis. Other research has evaluated the association between genetic polymorphisms in humans with different AP aspects; these studies pointed out that genetic polymorphisms in some candidate genes are involved in inter-individual variations in their response to AP. Therefore, the objective of this report was to provide an updated overview of the genes involved in AP pathogenesis, with a focus on the most relevant candidate genes. |
| first_indexed | 2024-12-14T05:09:43Z |
| format | Article |
| id | doaj.art-aa87096f66d548f9aaa7bb6f0438580c |
| institution | Directory Open Access Journal |
| issn | 1807-3107 |
| language | English |
| last_indexed | 2024-12-14T05:09:43Z |
| publishDate | 2018-10-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj.art-aa87096f66d548f9aaa7bb6f0438580c2022-12-21T23:16:00ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072018-10-0132suppl 110.1590/1807-3107bor-2018.vol32.0072S1806-83242018000500607Current trends of genetics in apical periodontitis researchErika Calvano KüchlerJardel Francisco Mazzi-ChavesLeonardo Santos AntunesChristian KirschneckFlares Baratto-FilhoManoel Damião Sousa-NetoAbstract: Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidate genes and AP. Some studies have been conducted on knockout mice with a deficiency in certain proteins, leading to more or less severe AP, and thus suggesting a pivotal role of these genes in AP pathogenesis. Other research has evaluated the association between genetic polymorphisms in humans with different AP aspects; these studies pointed out that genetic polymorphisms in some candidate genes are involved in inter-individual variations in their response to AP. Therefore, the objective of this report was to provide an updated overview of the genes involved in AP pathogenesis, with a focus on the most relevant candidate genes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500607&lng=en&tlng=enPeriapical PeriodontitisPolymorphismsGeneticGenesPathologyEndodontics |
| spellingShingle | Erika Calvano Küchler Jardel Francisco Mazzi-Chaves Leonardo Santos Antunes Christian Kirschneck Flares Baratto-Filho Manoel Damião Sousa-Neto Current trends of genetics in apical periodontitis research Brazilian Oral Research Periapical Periodontitis Polymorphisms Genetic Genes Pathology Endodontics |
| title | Current trends of genetics in apical periodontitis research |
| title_full | Current trends of genetics in apical periodontitis research |
| title_fullStr | Current trends of genetics in apical periodontitis research |
| title_full_unstemmed | Current trends of genetics in apical periodontitis research |
| title_short | Current trends of genetics in apical periodontitis research |
| title_sort | current trends of genetics in apical periodontitis research |
| topic | Periapical Periodontitis Polymorphisms Genetic Genes Pathology Endodontics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500607&lng=en&tlng=en |
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