A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational Research
Background: The aim of this study was to develop a prognostic model to identify a subgroup of high-risk patients for non-healing after femoral neck fracture fixation among young adults. The model was implemented by presenting graphically as a nomogram that could be easily used in every day clinical...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2022-03-01
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| Series: | Journal of Orthopedic and Spine Trauma |
| Subjects: | |
| Online Access: | https://jost.tums.ac.ir/index.php/jost/article/view/295 |
| _version_ | 1811271792317169664 |
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| author | Babak Siavashi Mohammad Heshmati Mohammad Reza Golbakhsh Seyyed Hossein Shafiei Farhad Mahdavi Mohammadreza Sadeghi Yegane Yousefifar Salar Baghbani Mohammadreza Bozorgmanesh |
| author_facet | Babak Siavashi Mohammad Heshmati Mohammad Reza Golbakhsh Seyyed Hossein Shafiei Farhad Mahdavi Mohammadreza Sadeghi Yegane Yousefifar Salar Baghbani Mohammadreza Bozorgmanesh |
| author_sort | Babak Siavashi |
| collection | DOAJ |
| description |
Background: The aim of this study was to develop a prognostic model to identify a subgroup of high-risk patients for non-healing after femoral neck fracture fixation among young adults. The model was implemented by presenting graphically as a nomogram that could be easily used in every day clinical cases.
Methods: Data on a total of 129 patients were included in the current study. The mean [standard deviation (SD)] age of the participants was 42 (13) years and 28% of the patients were women. Harrell’s C statistic was used as a measure of discrimination predictive power. We calculated the Nam-D’Agostino χ2 to examine calibration for prediction models.
Results: Approximately, 83% of fractures united uneventfully, with avascular necrosis (AVN), fixation nonhealing, non-union, infection, arthroplasty, and death being observed. Body mass index (BMI) and head acetabular trabecular angle (HATA) were inversely associated with the risk of all-cause nonhealing. The final model showed excellent discriminatory power [Harrell’s C statistic: 0.820, 95% confidence interval (CI) (0.680-0.960)] and it was well-calibrated [Nam-D’Agostino χ2: 10.1, (P = 0.3456)]. A
nomogram developed by incorporating significant predictors modelled without discretizing continuous variables.
Conclusion: Using readily available clinical and radiological data, we developed a parsimonious, simple, accurate yardstick to measure the 5-year risk of nonhealing after femoral neck fractures among young adults. In order to add ease-of-use and to promote its integration into clinical practice, the prognostic model was demonstrated visually as a statistic nomogram.
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| first_indexed | 2024-04-12T22:27:30Z |
| format | Article |
| id | doaj.art-aa8a8f5042a0421eada75f5eb5f5703c |
| institution | Directory Open Access Journal |
| issn | 2538-2330 2538-4600 |
| language | English |
| last_indexed | 2024-04-12T22:27:30Z |
| publishDate | 2022-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Orthopedic and Spine Trauma |
| spelling | doaj.art-aa8a8f5042a0421eada75f5eb5f5703c2022-12-22T03:14:04ZengTehran University of Medical SciencesJournal of Orthopedic and Spine Trauma2538-23302538-46002022-03-017310.18502/jost.v7i3.8104A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational ResearchBabak Siavashi0Mohammad Heshmati1Mohammad Reza Golbakhsh2Seyyed Hossein Shafiei3Farhad Mahdavi4Mohammadreza Sadeghi5Yegane Yousefifar6Salar Baghbani7Mohammadreza Bozorgmanesh8Department of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics, Vali-e-Asr Hospital, School of Medicine, Arak University of Medical Sciences, Arak, Iran Background: The aim of this study was to develop a prognostic model to identify a subgroup of high-risk patients for non-healing after femoral neck fracture fixation among young adults. The model was implemented by presenting graphically as a nomogram that could be easily used in every day clinical cases. Methods: Data on a total of 129 patients were included in the current study. The mean [standard deviation (SD)] age of the participants was 42 (13) years and 28% of the patients were women. Harrell’s C statistic was used as a measure of discrimination predictive power. We calculated the Nam-D’Agostino χ2 to examine calibration for prediction models. Results: Approximately, 83% of fractures united uneventfully, with avascular necrosis (AVN), fixation nonhealing, non-union, infection, arthroplasty, and death being observed. Body mass index (BMI) and head acetabular trabecular angle (HATA) were inversely associated with the risk of all-cause nonhealing. The final model showed excellent discriminatory power [Harrell’s C statistic: 0.820, 95% confidence interval (CI) (0.680-0.960)] and it was well-calibrated [Nam-D’Agostino χ2: 10.1, (P = 0.3456)]. A nomogram developed by incorporating significant predictors modelled without discretizing continuous variables. Conclusion: Using readily available clinical and radiological data, we developed a parsimonious, simple, accurate yardstick to measure the 5-year risk of nonhealing after femoral neck fractures among young adults. In order to add ease-of-use and to promote its integration into clinical practice, the prognostic model was demonstrated visually as a statistic nomogram. https://jost.tums.ac.ir/index.php/jost/article/view/295Femoral Neck Fracture; Nomograms; Risk |
| spellingShingle | Babak Siavashi Mohammad Heshmati Mohammad Reza Golbakhsh Seyyed Hossein Shafiei Farhad Mahdavi Mohammadreza Sadeghi Yegane Yousefifar Salar Baghbani Mohammadreza Bozorgmanesh A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational Research Journal of Orthopedic and Spine Trauma Femoral Neck Fracture; Nomograms; Risk |
| title | A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational Research |
| title_full | A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational Research |
| title_fullStr | A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational Research |
| title_full_unstemmed | A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational Research |
| title_short | A Web-Based Dynamic Nomogram to Calculate the Risk of Nonhealing after Femoral Neck Fracture Fixation among Young Adults: Bench to Bedside Translational Research |
| title_sort | web based dynamic nomogram to calculate the risk of nonhealing after femoral neck fracture fixation among young adults bench to bedside translational research |
| topic | Femoral Neck Fracture; Nomograms; Risk |
| url | https://jost.tums.ac.ir/index.php/jost/article/view/295 |
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