Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology
Abstract Isatis indigotica Fort. (Chinese woad) is a species with an ancient and well-documented history as an indigo dye and medicinal plant. It is often confused with Isatis tinctoria L. (European woad), a medicinal plant in Europe. Here, the differences between I. indigotica and I. tinctoria are...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Molecular Horticulture |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43897-021-00021-w |
| _version_ | 1798026789719638016 |
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| author | Jingxian Feng Doudou Huang Yingbo Yang Junfeng Chen Shi Qiu Zongyou Lv Xueqi Ma Yuanyu Li Rongrong Li Ying Xiao Wansheng Chen |
| author_facet | Jingxian Feng Doudou Huang Yingbo Yang Junfeng Chen Shi Qiu Zongyou Lv Xueqi Ma Yuanyu Li Rongrong Li Ying Xiao Wansheng Chen |
| author_sort | Jingxian Feng |
| collection | DOAJ |
| description | Abstract Isatis indigotica Fort. (Chinese woad) is a species with an ancient and well-documented history as an indigo dye and medicinal plant. It is often confused with Isatis tinctoria L. (European woad), a medicinal plant in Europe. Here, the differences between I. indigotica and I. tinctoria are systematically described. The usage development history, clinical applications and pharmacological activities, and chemical components of I. indigotica are also summarized. Lignans, indole alkaloids, and their corresponding derivatives have been identified as the major active ingredients of I. indigotica and are associated with anti-viral, anti-inflammatory, anti-cancer, and other health-promoting activities. Notable progress has been made in understanding the biosynthetic pathway and regulation mechanism of lignans and indole alkaloids in I. indigotica, the results from which should facilitate the process of targeted metabolic engineering or synthetic biology. Moreover, multiple biotechnology methods such as polyploid breeding and genetic engineering have been used with I. indigotica to result in, for example, greater yields, higher levels of bioactive component accumulation, and enhanced stress tolerance to salt, drought, and insects. Some issues require additional analyses, and suggestions for future research on I. indigotica are also discussed. |
| first_indexed | 2024-04-11T18:41:00Z |
| format | Article |
| id | doaj.art-aa90ce00d93d4d3683f4f811a7691653 |
| institution | Directory Open Access Journal |
| issn | 2730-9401 |
| language | English |
| last_indexed | 2024-04-11T18:41:00Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Horticulture |
| spelling | doaj.art-aa90ce00d93d4d3683f4f811a76916532022-12-22T04:08:58ZengBMCMolecular Horticulture2730-94012021-12-011111410.1186/s43897-021-00021-wIsatis indigotica: from (ethno) botany, biochemistry to synthetic biologyJingxian Feng0Doudou Huang1Yingbo Yang2Junfeng Chen3Shi Qiu4Zongyou Lv5Xueqi Ma6Yuanyu Li7Rongrong Li8Ying Xiao9Wansheng Chen10Research and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineResearch and Development Center of Chinese Medicine Resources and Biotechnology, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese MedicineAbstract Isatis indigotica Fort. (Chinese woad) is a species with an ancient and well-documented history as an indigo dye and medicinal plant. It is often confused with Isatis tinctoria L. (European woad), a medicinal plant in Europe. Here, the differences between I. indigotica and I. tinctoria are systematically described. The usage development history, clinical applications and pharmacological activities, and chemical components of I. indigotica are also summarized. Lignans, indole alkaloids, and their corresponding derivatives have been identified as the major active ingredients of I. indigotica and are associated with anti-viral, anti-inflammatory, anti-cancer, and other health-promoting activities. Notable progress has been made in understanding the biosynthetic pathway and regulation mechanism of lignans and indole alkaloids in I. indigotica, the results from which should facilitate the process of targeted metabolic engineering or synthetic biology. Moreover, multiple biotechnology methods such as polyploid breeding and genetic engineering have been used with I. indigotica to result in, for example, greater yields, higher levels of bioactive component accumulation, and enhanced stress tolerance to salt, drought, and insects. Some issues require additional analyses, and suggestions for future research on I. indigotica are also discussed.https://doi.org/10.1186/s43897-021-00021-wIsatis indigoticaLignansIndole alkaloidsMetabolic engineeringSynthetic biology |
| spellingShingle | Jingxian Feng Doudou Huang Yingbo Yang Junfeng Chen Shi Qiu Zongyou Lv Xueqi Ma Yuanyu Li Rongrong Li Ying Xiao Wansheng Chen Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology Molecular Horticulture Isatis indigotica Lignans Indole alkaloids Metabolic engineering Synthetic biology |
| title | Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology |
| title_full | Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology |
| title_fullStr | Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology |
| title_full_unstemmed | Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology |
| title_short | Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology |
| title_sort | isatis indigotica from ethno botany biochemistry to synthetic biology |
| topic | Isatis indigotica Lignans Indole alkaloids Metabolic engineering Synthetic biology |
| url | https://doi.org/10.1186/s43897-021-00021-w |
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