Inflammasomes in Cancer Progression and Anti-Tumor Immunity
The inflammasomes are critical regulators of innate immunity, inflammation and cell death and have emerged as important regulators of cancer development and control. Inflammasomes are assembled by pattern recognition receptors (PRR) following the sensing of microbial- or danger-associated molecular...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.839041/full |
| _version_ | 1818481649748279296 |
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| author | Sebastian Lillo Maya Saleh Maya Saleh |
| author_facet | Sebastian Lillo Maya Saleh Maya Saleh |
| author_sort | Sebastian Lillo |
| collection | DOAJ |
| description | The inflammasomes are critical regulators of innate immunity, inflammation and cell death and have emerged as important regulators of cancer development and control. Inflammasomes are assembled by pattern recognition receptors (PRR) following the sensing of microbial- or danger-associated molecular patterns (MAMPs/DAMPs) and elicit inflammation through the oligomerization and activation of inflammatory caspases. These cysteinyl-aspartate proteases cleave the proinflammatory cytokines IL-1β and IL-18 into their biologically active mature form. The roles of the inflammasomes and associated pro-inflammatory cytokines vary greatly depending on the cancer type. Here we discuss recent studies highlighting contrasting roles of the inflammasome pathway in curbing versus promoting tumorigenesis. On one hand, the inflammasomes participate in stimulating anti-tumor immunity, but they have also been shown to contribute to immunosuppression or to directly promote tumor cell survival, proliferation, and metastasis. A better understanding of inflammasome functions in different cancers is thus critical for the design of novel cancer immunotherapies. |
| first_indexed | 2024-12-10T11:37:45Z |
| format | Article |
| id | doaj.art-aa917a2b6b1d4d7ab711ac1acd02735c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-10T11:37:45Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-aa917a2b6b1d4d7ab711ac1acd02735c2022-12-22T01:50:23ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.839041839041Inflammasomes in Cancer Progression and Anti-Tumor ImmunitySebastian Lillo0Maya Saleh1Maya Saleh2CNRS, ImmunoConcEpT, UMR 5164, University of Bordeaux, Bordeaux, FranceCNRS, ImmunoConcEpT, UMR 5164, University of Bordeaux, Bordeaux, Francegt; 2Adjunct Professor, Department of Medicine, McGill University, Montreal, QC, CanadaThe inflammasomes are critical regulators of innate immunity, inflammation and cell death and have emerged as important regulators of cancer development and control. Inflammasomes are assembled by pattern recognition receptors (PRR) following the sensing of microbial- or danger-associated molecular patterns (MAMPs/DAMPs) and elicit inflammation through the oligomerization and activation of inflammatory caspases. These cysteinyl-aspartate proteases cleave the proinflammatory cytokines IL-1β and IL-18 into their biologically active mature form. The roles of the inflammasomes and associated pro-inflammatory cytokines vary greatly depending on the cancer type. Here we discuss recent studies highlighting contrasting roles of the inflammasome pathway in curbing versus promoting tumorigenesis. On one hand, the inflammasomes participate in stimulating anti-tumor immunity, but they have also been shown to contribute to immunosuppression or to directly promote tumor cell survival, proliferation, and metastasis. A better understanding of inflammasome functions in different cancers is thus critical for the design of novel cancer immunotherapies.https://www.frontiersin.org/articles/10.3389/fcell.2022.839041/fullInflammasomecaspasepyroptosistumorimmunotherapymacrophages |
| spellingShingle | Sebastian Lillo Maya Saleh Maya Saleh Inflammasomes in Cancer Progression and Anti-Tumor Immunity Frontiers in Cell and Developmental Biology Inflammasome caspase pyroptosis tumor immunotherapy macrophages |
| title | Inflammasomes in Cancer Progression and Anti-Tumor Immunity |
| title_full | Inflammasomes in Cancer Progression and Anti-Tumor Immunity |
| title_fullStr | Inflammasomes in Cancer Progression and Anti-Tumor Immunity |
| title_full_unstemmed | Inflammasomes in Cancer Progression and Anti-Tumor Immunity |
| title_short | Inflammasomes in Cancer Progression and Anti-Tumor Immunity |
| title_sort | inflammasomes in cancer progression and anti tumor immunity |
| topic | Inflammasome caspase pyroptosis tumor immunotherapy macrophages |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.839041/full |
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