A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIA
Introduction. The colonic pathology associated with the administration of nonsteroidal anti-inflammatory drugs is vast and includes inflammation, ulcerations and sometimes strictures. It is important to identify the NSAIDs-induced alterations in the colon in order to differentiate them from other p...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2018-09-01
|
| Series: | Romanian Journal of Medical Practice |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_Journal_of_MEDICAL_PRACTICE/Practica_medicala-2018-Nr.3/RJMP_2018_3_Art-08.pdf |
| _version_ | 1831586055188381696 |
|---|---|
| author | Ecaterina Rinja Madalina Ilie Vasile Sandru Irina Diaconu Oana Plotogea Andreea Hortopan Ruxandra Oprita Alexandru Laurentiu Chiotoroiu Gabriel Constantinescu |
| author_facet | Ecaterina Rinja Madalina Ilie Vasile Sandru Irina Diaconu Oana Plotogea Andreea Hortopan Ruxandra Oprita Alexandru Laurentiu Chiotoroiu Gabriel Constantinescu |
| author_sort | Ecaterina Rinja |
| collection | DOAJ |
| description | Introduction. The colonic pathology associated with the administration of nonsteroidal anti-inflammatory drugs is vast and includes inflammation, ulcerations and sometimes strictures. It is important to
identify the NSAIDs-induced alterations in the colon in order to differentiate them from other pathologies
and to avoid treatment errors.
The objective of this paper is to present a post-NSAIDs colopathy revealed by lower digestive bleeding –
hematochezia.
Material and methods. A 68 years old patient under treatment with NSAIDs is hospitalized for hematochezia. Laboratory tests, upper and lower digestive endoscopy are performed and multiple colonic ulcers
are identified.
Results. Following the investigations, the suspicion of post-NSAIDs colonic ulcers is raised and a differential diagnosis with inflammatory bowel disease is sought by taking multiple biopsies. The histopathological examination shows ischemic necrosis, with no pathognomonic elements linked to Crohn’s disease.
Conclusions. The peculiarity of this case resides in the importance of identifying the NSAIDs-induced
pathology and differentiating it from other pathologies to prevent treatment errors. Associating multiple
ulcers in NSAIDs pathology is rare and often misdiagnosed as Crohn's disease. Keep in mind the importance of the histopathologic exam, which excluded the inflammatory bowel disease in a patient with inconclusive inflammatory biological evidence. |
| first_indexed | 2024-12-17T21:29:43Z |
| format | Article |
| id | doaj.art-aa94f7b8600542aaa59150751c2f15bf |
| institution | Directory Open Access Journal |
| issn | 1842-8258 2069-6108 |
| language | English |
| last_indexed | 2024-12-17T21:29:43Z |
| publishDate | 2018-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Medical Practice |
| spelling | doaj.art-aa94f7b8600542aaa59150751c2f15bf2022-12-21T21:31:56ZengAmaltea Medical Publishing HouseRomanian Journal of Medical Practice1842-82582069-61082018-09-0113321421610.37897/RJMP.2018.3.8A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIAEcaterina Rinja0Madalina Ilie1Vasile Sandru2Irina Diaconu3Oana Plotogea4Andreea Hortopan5Ruxandra Oprita6Alexandru Laurentiu Chiotoroiu7Gabriel Constantinescu8Gastroenterology Department, Clinical Emergency Hospital, BucharestGastroenterology Department, Clinical Emergency Hospital, Bucharest; “Carol Davila” University of Medicine and Pharmacy, BucharestGastroenterology Department, Clinical Emergency Hospital, BucharestGastroenterology Department, Clinical Emergency Hospital, BucharestGastroenterology Department, Clinical Emergency Hospital, BucharestGastroenterology Department, Clinical Emergency Hospital, BucharestGastroenterology Department, Clinical Emergency Hospital, Bucharest; “Carol Davila” University of Medicine and Pharmacy, BucharestSurgery Department, Clinical Emergency Hospital, BucharestGastroenterology Department, Clinical Emergency Hospital, Bucharest; “Carol Davila” University of Medicine and Pharmacy, BucharestIntroduction. The colonic pathology associated with the administration of nonsteroidal anti-inflammatory drugs is vast and includes inflammation, ulcerations and sometimes strictures. It is important to identify the NSAIDs-induced alterations in the colon in order to differentiate them from other pathologies and to avoid treatment errors. The objective of this paper is to present a post-NSAIDs colopathy revealed by lower digestive bleeding – hematochezia. Material and methods. A 68 years old patient under treatment with NSAIDs is hospitalized for hematochezia. Laboratory tests, upper and lower digestive endoscopy are performed and multiple colonic ulcers are identified. Results. Following the investigations, the suspicion of post-NSAIDs colonic ulcers is raised and a differential diagnosis with inflammatory bowel disease is sought by taking multiple biopsies. The histopathological examination shows ischemic necrosis, with no pathognomonic elements linked to Crohn’s disease. Conclusions. The peculiarity of this case resides in the importance of identifying the NSAIDs-induced pathology and differentiating it from other pathologies to prevent treatment errors. Associating multiple ulcers in NSAIDs pathology is rare and often misdiagnosed as Crohn's disease. Keep in mind the importance of the histopathologic exam, which excluded the inflammatory bowel disease in a patient with inconclusive inflammatory biological evidence.https://revistemedicale.amaltea.ro/Romanian_Journal_of_MEDICAL_PRACTICE/Practica_medicala-2018-Nr.3/RJMP_2018_3_Art-08.pdfcolonic ulcerscolopathynsaids |
| spellingShingle | Ecaterina Rinja Madalina Ilie Vasile Sandru Irina Diaconu Oana Plotogea Andreea Hortopan Ruxandra Oprita Alexandru Laurentiu Chiotoroiu Gabriel Constantinescu A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIA Romanian Journal of Medical Practice colonic ulcers colopathy nsaids |
| title | A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIA |
| title_full | A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIA |
| title_fullStr | A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIA |
| title_full_unstemmed | A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIA |
| title_short | A RARE CASE OF MULTIPLE COLONIC ULCERS REVEALED BY HEMATOCHEZIA |
| title_sort | rare case of multiple colonic ulcers revealed by hematochezia |
| topic | colonic ulcers colopathy nsaids |
| url | https://revistemedicale.amaltea.ro/Romanian_Journal_of_MEDICAL_PRACTICE/Practica_medicala-2018-Nr.3/RJMP_2018_3_Art-08.pdf |
| work_keys_str_mv | AT ecaterinarinja ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT madalinailie ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT vasilesandru ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT irinadiaconu ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT oanaplotogea ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT andreeahortopan ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT ruxandraoprita ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT alexandrulaurentiuchiotoroiu ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT gabrielconstantinescu ararecaseofmultiplecoloniculcersrevealedbyhematochezia AT ecaterinarinja rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT madalinailie rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT vasilesandru rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT irinadiaconu rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT oanaplotogea rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT andreeahortopan rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT ruxandraoprita rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT alexandrulaurentiuchiotoroiu rarecaseofmultiplecoloniculcersrevealedbyhematochezia AT gabrielconstantinescu rarecaseofmultiplecoloniculcersrevealedbyhematochezia |