Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetes
Background and Aim: Based on recent studies, atorvastatin has some pleiotropic actions such as anti-inflammatory and anti-oxidant effects independent of lipid lowering effects. Regarding the critical role of oxidative stress and inflammation in inducing diabetic neuropathy, the current study aimed a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | fas |
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Birjand University of Medical Sciences and Health Services
2015-04-01
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| Series: | مجله دانشگاه علوم پزشکی بیرجند |
| Subjects: | |
| Online Access: | http://journal.bums.ac.ir/browse.php?a_code=A-10-1303-2&slc_lang=en&sid=1 |
| _version_ | 1811233167946809344 |
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| author | Nastaran Faghihi Mohammad Taghi Mohammadi Fatemeh Salem |
| author_facet | Nastaran Faghihi Mohammad Taghi Mohammadi Fatemeh Salem |
| author_sort | Nastaran Faghihi |
| collection | DOAJ |
| description | Background and Aim: Based on recent studies, atorvastatin has some pleiotropic actions such as anti-inflammatory and anti-oxidant effects independent of lipid lowering effects. Regarding the critical role of oxidative stress and inflammation in inducing diabetic neuropathy, the current study aimed at examining the neuroprotective and anti-oxidative stress effects of atorvastatin atthe brain tissues in diabetes experimental models.
Materials and Methods: Twenty-four male Wistar rats were randomly divided into 4 equal groups . including normal, normal treated, diabetic and diabetic treated. The diabetic group were made diabetic by an intravenous injection of streptozotocin (40mg/kg) and the treated group received 40mg/kg/day atorvastatin for 8weeks. At the end of the experiment, blood samples from the subjects were derived to measure their blood glucose and urea. Finally, the rats were killed under deep anesthesia and their brains were removed in order to measure malondialdehyde (MDA) and to make histopathological assessment.
Results: Uncontrolled hyperglycemia (blood glucose >450 mg/dl) significantly increased blood urea in the diabetic group (130±10 mg/dl) compared with the normal group (58±7 mg/dl), (P<0.05). Also, hyperglycemia increased brain MDA of the diabetic group (8.78±3.07µmol/mg protein) associated with histopathological damages. Atorvastatin significantly decreased blood urea of the diabetic rats (76±5 mg/dl) accompanied by histopathological damages. Finally, the content of brain MDA significantly . decreased in diabetic rats treated with atorvastatin (0.92±0.31µmol/mg protein), (P<0.05).
Conclusion: The findings of the present study reveal that atorvastatin is able to prevent hyperglycemia-induced diabetic neuropathy and inhibit brain oxidative stress during diabetes. It is probable that reduction of urea is one of the reasons for atorvastatin prevention of hyperglycemia-induced neuropathy. |
| first_indexed | 2024-04-12T11:16:01Z |
| format | Article |
| id | doaj.art-aa9794eca29945669c609ddf5291cb70 |
| institution | Directory Open Access Journal |
| issn | 1607-2197 2423-6152 |
| language | fas |
| last_indexed | 2024-04-12T11:16:01Z |
| publishDate | 2015-04-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj.art-aa9794eca29945669c609ddf5291cb702022-12-22T03:35:29ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522015-04-012214858Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetesNastaran Faghihi0Mohammad Taghi Mohammadi1Fatemeh Salem2 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran; Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran; Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Background and Aim: Based on recent studies, atorvastatin has some pleiotropic actions such as anti-inflammatory and anti-oxidant effects independent of lipid lowering effects. Regarding the critical role of oxidative stress and inflammation in inducing diabetic neuropathy, the current study aimed at examining the neuroprotective and anti-oxidative stress effects of atorvastatin atthe brain tissues in diabetes experimental models. Materials and Methods: Twenty-four male Wistar rats were randomly divided into 4 equal groups . including normal, normal treated, diabetic and diabetic treated. The diabetic group were made diabetic by an intravenous injection of streptozotocin (40mg/kg) and the treated group received 40mg/kg/day atorvastatin for 8weeks. At the end of the experiment, blood samples from the subjects were derived to measure their blood glucose and urea. Finally, the rats were killed under deep anesthesia and their brains were removed in order to measure malondialdehyde (MDA) and to make histopathological assessment. Results: Uncontrolled hyperglycemia (blood glucose >450 mg/dl) significantly increased blood urea in the diabetic group (130±10 mg/dl) compared with the normal group (58±7 mg/dl), (P<0.05). Also, hyperglycemia increased brain MDA of the diabetic group (8.78±3.07µmol/mg protein) associated with histopathological damages. Atorvastatin significantly decreased blood urea of the diabetic rats (76±5 mg/dl) accompanied by histopathological damages. Finally, the content of brain MDA significantly . decreased in diabetic rats treated with atorvastatin (0.92±0.31µmol/mg protein), (P<0.05). Conclusion: The findings of the present study reveal that atorvastatin is able to prevent hyperglycemia-induced diabetic neuropathy and inhibit brain oxidative stress during diabetes. It is probable that reduction of urea is one of the reasons for atorvastatin prevention of hyperglycemia-induced neuropathy.http://journal.bums.ac.ir/browse.php?a_code=A-10-1303-2&slc_lang=en&sid=1Diabetic neuropathy Atorvastatin Hyperglycemia Uremia Oxidative stress |
| spellingShingle | Nastaran Faghihi Mohammad Taghi Mohammadi Fatemeh Salem Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetes مجله دانشگاه علوم پزشکی بیرجند Diabetic neuropathy Atorvastatin Hyperglycemia Uremia Oxidative stress |
| title | Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetes |
| title_full | Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetes |
| title_fullStr | Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetes |
| title_full_unstemmed | Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetes |
| title_short | Effect of atorvastatin on hyperglycemia-induced brain oxidative stress and neuropathy induced by diabetes |
| title_sort | effect of atorvastatin on hyperglycemia induced brain oxidative stress and neuropathy induced by diabetes |
| topic | Diabetic neuropathy Atorvastatin Hyperglycemia Uremia Oxidative stress |
| url | http://journal.bums.ac.ir/browse.php?a_code=A-10-1303-2&slc_lang=en&sid=1 |
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