The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment
Background Alcohol use disorder (AUD)-induced disruption of oral microbiota can lead to poor oral health; there have been no studies published examining the longitudinal effects of alcohol use cessation on the oral microbiome. Aim To investigate the oral microbiome during alcohol cessation during in...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-01-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20002297.2021.2004790 |
| _version_ | 1818700084377812992 |
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| author | JJ Barb KA Maki N Kazmi BK Meeks M Krumlauf RT Tuason AT Brooks NJ Ames D Goldman GR Wallen |
| author_facet | JJ Barb KA Maki N Kazmi BK Meeks M Krumlauf RT Tuason AT Brooks NJ Ames D Goldman GR Wallen |
| author_sort | JJ Barb |
| collection | DOAJ |
| description | Background Alcohol use disorder (AUD)-induced disruption of oral microbiota can lead to poor oral health; there have been no studies published examining the longitudinal effects of alcohol use cessation on the oral microbiome. Aim To investigate the oral microbiome during alcohol cessation during inpatient treatment for AUD. Methods Up to 10 oral tongue brushings were collected from 22 AUD patients during inpatient treatment at the National Institutes of Health. Alcohol use history, smoking, and periodontal disease status were measured. Oral microbiome samples were sequenced using 16S rRNA gene sequencing. Results Alpha diversity decreased linearly during treatment across the entire cohort (P = 0.002). Alcohol preference was associated with changes in both alpha and beta diversity measures. Characteristic tongue dorsum genera from the Human Microbiome Project such as Streptococcus, Prevotella, Veillonella and Haemophilus were highly correlated in AUD. Oral health-associated genera that changed longitudinally during abstinence included Actinomyces, Capnocytophaga, Fusobacterium, Neisseria and Prevotella. Conclusion The oral microbiome in AUD is affected by alcohol preference. Patients with AUD often have poor oral health but abstinence and attention to oral care improve dysbiosis, decreasing microbiome diversity and periodontal disease-associated genera while improving acute oral health. |
| first_indexed | 2024-12-17T14:59:19Z |
| format | Article |
| id | doaj.art-aa9af47f1fde4c8c81a94da8dd6ffa24 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-17T14:59:19Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-aa9af47f1fde4c8c81a94da8dd6ffa242022-12-21T21:43:56ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972022-01-0114110.1080/20002297.2021.20047902004790The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatmentJJ Barb0KA Maki1N Kazmi2BK Meeks3M Krumlauf4RT Tuason5AT Brooks6NJ Ames7D Goldman8GR Wallen9National Institutes of Health, Clinical CenterNational Institutes of Health, Clinical CenterNational Institutes of Health, Clinical CenterNational Institutes of Health, Clinical CenterNational Institutes of Health, Clinical CenterNational Institutes of Health, Clinical CenterCenter for Scientific Review, National Institutes of HealthNational Institutes of Health, Clinical CenterLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthNational Institutes of Health, Clinical CenterBackground Alcohol use disorder (AUD)-induced disruption of oral microbiota can lead to poor oral health; there have been no studies published examining the longitudinal effects of alcohol use cessation on the oral microbiome. Aim To investigate the oral microbiome during alcohol cessation during inpatient treatment for AUD. Methods Up to 10 oral tongue brushings were collected from 22 AUD patients during inpatient treatment at the National Institutes of Health. Alcohol use history, smoking, and periodontal disease status were measured. Oral microbiome samples were sequenced using 16S rRNA gene sequencing. Results Alpha diversity decreased linearly during treatment across the entire cohort (P = 0.002). Alcohol preference was associated with changes in both alpha and beta diversity measures. Characteristic tongue dorsum genera from the Human Microbiome Project such as Streptococcus, Prevotella, Veillonella and Haemophilus were highly correlated in AUD. Oral health-associated genera that changed longitudinally during abstinence included Actinomyces, Capnocytophaga, Fusobacterium, Neisseria and Prevotella. Conclusion The oral microbiome in AUD is affected by alcohol preference. Patients with AUD often have poor oral health but abstinence and attention to oral care improve dysbiosis, decreasing microbiome diversity and periodontal disease-associated genera while improving acute oral health.http://dx.doi.org/10.1080/20002297.2021.2004790oral microbiomealcohol use disorderion torrent16s rrnaboasperiodontal diseasehmp |
| spellingShingle | JJ Barb KA Maki N Kazmi BK Meeks M Krumlauf RT Tuason AT Brooks NJ Ames D Goldman GR Wallen The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment Journal of Oral Microbiology oral microbiome alcohol use disorder ion torrent 16s rrna boas periodontal disease hmp |
| title | The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment |
| title_full | The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment |
| title_fullStr | The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment |
| title_full_unstemmed | The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment |
| title_short | The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment |
| title_sort | oral microbiome in alcohol use disorder a longitudinal analysis during inpatient treatment |
| topic | oral microbiome alcohol use disorder ion torrent 16s rrna boas periodontal disease hmp |
| url | http://dx.doi.org/10.1080/20002297.2021.2004790 |
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