C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
Hereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans TTDA ortholog GTF-2H5 is, compatible with life, in...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02875-8 |
| _version_ | 1818405621548974080 |
|---|---|
| author | Karen L. Thijssen Melanie van der Woude Carlota Davó-Martínez Dick H. W. Dekkers Mariangela Sabatella Jeroen A. A. Demmers Wim Vermeulen Hannes Lans |
| author_facet | Karen L. Thijssen Melanie van der Woude Carlota Davó-Martínez Dick H. W. Dekkers Mariangela Sabatella Jeroen A. A. Demmers Wim Vermeulen Hannes Lans |
| author_sort | Karen L. Thijssen |
| collection | DOAJ |
| description | Hereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans TTDA ortholog GTF-2H5 is, compatible with life, in contrast to depletion of other TFIIH subunits and thus propose that this model could be used for studying the pathogenesis of trichothiodystrophy. |
| first_indexed | 2024-12-14T08:58:58Z |
| format | Article |
| id | doaj.art-aa9b284b2d79417c957d8200b1542823 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T08:58:58Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-aa9b284b2d79417c957d8200b15428232022-12-21T23:08:51ZengNature PortfolioCommunications Biology2399-36422021-11-014111210.1038/s42003-021-02875-8C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repairKaren L. Thijssen0Melanie van der Woude1Carlota Davó-Martínez2Dick H. W. Dekkers3Mariangela Sabatella4Jeroen A. A. Demmers5Wim Vermeulen6Hannes Lans7Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical CenterDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical CenterDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical CenterProteomics Center, Erasmus University Medical CenterDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical CenterProteomics Center, Erasmus University Medical CenterDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical CenterDepartment of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical CenterHereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans TTDA ortholog GTF-2H5 is, compatible with life, in contrast to depletion of other TFIIH subunits and thus propose that this model could be used for studying the pathogenesis of trichothiodystrophy.https://doi.org/10.1038/s42003-021-02875-8 |
| spellingShingle | Karen L. Thijssen Melanie van der Woude Carlota Davó-Martínez Dick H. W. Dekkers Mariangela Sabatella Jeroen A. A. Demmers Wim Vermeulen Hannes Lans C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair Communications Biology |
| title | C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair |
| title_full | C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair |
| title_fullStr | C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair |
| title_full_unstemmed | C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair |
| title_short | C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair |
| title_sort | c elegans tfiih subunit gtf 2h5 ttda is a non essential transcription factor indispensable for dna repair |
| url | https://doi.org/10.1038/s42003-021-02875-8 |
| work_keys_str_mv | AT karenlthijssen celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair AT melanievanderwoude celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair AT carlotadavomartinez celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair AT dickhwdekkers celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair AT mariangelasabatella celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair AT jeroenaademmers celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair AT wimvermeulen celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair AT hanneslans celeganstfiihsubunitgtf2h5ttdaisanonessentialtranscriptionfactorindispensablefordnarepair |