Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy
Abstract Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neutralization activities one month following the fir...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-022-00452-6 |
| _version_ | 1797643077589925888 |
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| author | Zabrina L. Brumme Francis Mwimanzi Hope R. Lapointe Peter K. Cheung Yurou Sang Maggie C. Duncan Fatima Yaseen Olga Agafitei Siobhan Ennis Kurtis Ng Simran Basra Li Yi Lim Rebecca Kalikawe Sarah Speckmaier Nadia Moran-Garcia Landon Young Hesham Ali Bruce Ganase Gisele Umviligihozo F. Harrison Omondi Kieran Atkinson Hanwei Sudderuddin Junine Toy Paul Sereda Laura Burns Cecilia T. Costiniuk Curtis Cooper Aslam H. Anis Victor Leung Daniel Holmes Mari L. DeMarco Janet Simons Malcolm Hedgcock Marc G. Romney Rolando Barrios Silvia Guillemi Chanson J. Brumme Ralph Pantophlet Julio S. G. Montaner Masahiro Niikura Marianne Harris Mark Hull Mark A. Brockman |
| author_facet | Zabrina L. Brumme Francis Mwimanzi Hope R. Lapointe Peter K. Cheung Yurou Sang Maggie C. Duncan Fatima Yaseen Olga Agafitei Siobhan Ennis Kurtis Ng Simran Basra Li Yi Lim Rebecca Kalikawe Sarah Speckmaier Nadia Moran-Garcia Landon Young Hesham Ali Bruce Ganase Gisele Umviligihozo F. Harrison Omondi Kieran Atkinson Hanwei Sudderuddin Junine Toy Paul Sereda Laura Burns Cecilia T. Costiniuk Curtis Cooper Aslam H. Anis Victor Leung Daniel Holmes Mari L. DeMarco Janet Simons Malcolm Hedgcock Marc G. Romney Rolando Barrios Silvia Guillemi Chanson J. Brumme Ralph Pantophlet Julio S. G. Montaner Masahiro Niikura Marianne Harris Mark Hull Mark A. Brockman |
| author_sort | Zabrina L. Brumme |
| collection | DOAJ |
| description | Abstract Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neutralization activities one month following the first and second COVID-19 vaccine doses, and again 3 months following the second dose, in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525–935) cells/mm3, though nadir CD4+ T-cell counts ranged as low as <10 cells/mm3. After adjustment for sociodemographic, health and vaccine-related variables, HIV infection was associated with lower anti-RBD antibody concentrations and ACE2 displacement activity after one vaccine dose. Following two doses however, HIV was not significantly associated with the magnitude of any humoral response after multivariable adjustment. Rather, older age, a higher burden of chronic health conditions, and dual ChAdOx1 vaccination were associated with lower responses after two vaccine doses. No significant correlation was observed between recent or nadir CD4+ T-cell counts and responses to two vaccine doses in PLWH. These results indicate that PLWH with well-controlled viral loads and CD4+ T-cell counts in a healthy range generally mount strong initial humoral responses to dual COVID-19 vaccination. Factors including age, co-morbidities, vaccine brand, response durability and the rise of new SARS-CoV-2 variants will influence when PLWH will benefit from additional doses. Further studies of PLWH who are not receiving antiretroviral treatment or who have low CD4+ T-cell counts are needed, as are longer-term assessments of response durability. |
| first_indexed | 2024-03-11T14:09:27Z |
| format | Article |
| id | doaj.art-aa9bbdca3ccd41fdb2e9b2db8e984af2 |
| institution | Directory Open Access Journal |
| issn | 2059-0105 |
| language | English |
| last_indexed | 2024-03-11T14:09:27Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj.art-aa9bbdca3ccd41fdb2e9b2db8e984af22023-11-02T00:37:04ZengNature Portfolionpj Vaccines2059-01052022-02-017111210.1038/s41541-022-00452-6Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapyZabrina L. Brumme0Francis Mwimanzi1Hope R. Lapointe2Peter K. Cheung3Yurou Sang4Maggie C. Duncan5Fatima Yaseen6Olga Agafitei7Siobhan Ennis8Kurtis Ng9Simran Basra10Li Yi Lim11Rebecca Kalikawe12Sarah Speckmaier13Nadia Moran-Garcia14Landon Young15Hesham Ali16Bruce Ganase17Gisele Umviligihozo18F. Harrison Omondi19Kieran Atkinson20Hanwei Sudderuddin21Junine Toy22Paul Sereda23Laura Burns24Cecilia T. Costiniuk25Curtis Cooper26Aslam H. Anis27Victor Leung28Daniel Holmes29Mari L. DeMarco30Janet Simons31Malcolm Hedgcock32Marc G. Romney33Rolando Barrios34Silvia Guillemi35Chanson J. Brumme36Ralph Pantophlet37Julio S. G. Montaner38Masahiro Niikura39Marianne Harris40Mark Hull41Mark A. Brockman42Faculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityBritish Columbia Centre for Excellence in HIV/AIDSFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityDepartment of Molecular Biology and Biochemistry, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityBritish Columbia Centre for Excellence in HIV/AIDSBritish Columbia Centre for Excellence in HIV/AIDSDivision of Medical Microbiology and Virology, St. Paul’s HospitalJohn Ruedy Clinic, St, Paul’s HospitalAIDS Research Program, St. Paul’s HospitalFaculty of Health Sciences, Simon Fraser UniversityFaculty of Health Sciences, Simon Fraser UniversityBritish Columbia Centre for Excellence in HIV/AIDSBritish Columbia Centre for Excellence in HIV/AIDSBritish Columbia Centre for Excellence in HIV/AIDSBritish Columbia Centre for Excellence in HIV/AIDSDepartment of Pathology and Laboratory Medicine, Providence Health CareDivision of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre and Research Institute of the McGill University Health CentreDepartment of Medicine, University of OttawaSchool of Population and Public Health, University of British ColumbiaDivision of Medical Microbiology and Virology, St. Paul’s HospitalDepartment of Pathology and Laboratory Medicine, Providence Health CareDepartment of Pathology and Laboratory Medicine, Providence Health CareDepartment of Pathology and Laboratory Medicine, Providence Health CareSpectrum HealthDivision of Medical Microbiology and Virology, St. Paul’s HospitalBritish Columbia Centre for Excellence in HIV/AIDSBritish Columbia Centre for Excellence in HIV/AIDSBritish Columbia Centre for Excellence in HIV/AIDSFaculty of Health Sciences, Simon Fraser UniversityBritish Columbia Centre for Excellence in HIV/AIDSFaculty of Health Sciences, Simon Fraser UniversityBritish Columbia Centre for Excellence in HIV/AIDSBritish Columbia Centre for Excellence in HIV/AIDSFaculty of Health Sciences, Simon Fraser UniversityAbstract Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neutralization activities one month following the first and second COVID-19 vaccine doses, and again 3 months following the second dose, in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525–935) cells/mm3, though nadir CD4+ T-cell counts ranged as low as <10 cells/mm3. After adjustment for sociodemographic, health and vaccine-related variables, HIV infection was associated with lower anti-RBD antibody concentrations and ACE2 displacement activity after one vaccine dose. Following two doses however, HIV was not significantly associated with the magnitude of any humoral response after multivariable adjustment. Rather, older age, a higher burden of chronic health conditions, and dual ChAdOx1 vaccination were associated with lower responses after two vaccine doses. No significant correlation was observed between recent or nadir CD4+ T-cell counts and responses to two vaccine doses in PLWH. These results indicate that PLWH with well-controlled viral loads and CD4+ T-cell counts in a healthy range generally mount strong initial humoral responses to dual COVID-19 vaccination. Factors including age, co-morbidities, vaccine brand, response durability and the rise of new SARS-CoV-2 variants will influence when PLWH will benefit from additional doses. Further studies of PLWH who are not receiving antiretroviral treatment or who have low CD4+ T-cell counts are needed, as are longer-term assessments of response durability.https://doi.org/10.1038/s41541-022-00452-6 |
| spellingShingle | Zabrina L. Brumme Francis Mwimanzi Hope R. Lapointe Peter K. Cheung Yurou Sang Maggie C. Duncan Fatima Yaseen Olga Agafitei Siobhan Ennis Kurtis Ng Simran Basra Li Yi Lim Rebecca Kalikawe Sarah Speckmaier Nadia Moran-Garcia Landon Young Hesham Ali Bruce Ganase Gisele Umviligihozo F. Harrison Omondi Kieran Atkinson Hanwei Sudderuddin Junine Toy Paul Sereda Laura Burns Cecilia T. Costiniuk Curtis Cooper Aslam H. Anis Victor Leung Daniel Holmes Mari L. DeMarco Janet Simons Malcolm Hedgcock Marc G. Romney Rolando Barrios Silvia Guillemi Chanson J. Brumme Ralph Pantophlet Julio S. G. Montaner Masahiro Niikura Marianne Harris Mark Hull Mark A. Brockman Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy npj Vaccines |
| title | Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy |
| title_full | Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy |
| title_fullStr | Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy |
| title_full_unstemmed | Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy |
| title_short | Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy |
| title_sort | humoral immune responses to covid 19 vaccination in people living with hiv receiving suppressive antiretroviral therapy |
| url | https://doi.org/10.1038/s41541-022-00452-6 |
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