Development and characterization of an intraocular biodegradable polymer system containing cyclosporine-A for the treatment of posterior uveitis

Development and characterization of an intraocular biodegradable polymer system containing cyclosporine-A for the treatment of posterior uveitis

The aim of this study was to synthesize and characterize the biodegradable intraocular implants based on poly (D,L-lactide-co-glycolide) (PLGA 75:25) with Cyclosporine-A (CyA) and to evaluate their in vitro drug delivery profile. Thermal analysis was conducted by using Thermogravimetry (TG) and Diff...

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Bibliographic Details
Main Authors: Juliana Barbosa Saliba, André Augusto Gomes Faraco, Maria Irene Yoshida, Wander Luiz de Vasconcelos, Armando da Silva-Cunha, Herman Sander Mansur
Format: Article
Language:English
Published: Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) 2008-06-01
Series:Materials Research
Subjects:
nanostructured drug delivery system
biodegradable intraocular implants
biodegradable polymer
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392008000200016

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