Consensus on early detection of disease progression in patients with multiple sclerosis
BackgroundEarly identification of the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) can be challenging for clinicians, as diagnostic criteria for SPMS are primarily based on physical disability and a holistic interpretation.ObjectiveTo establish a c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.931014/full |
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| author | José E. Meca-Lallana Bonaventura Casanova Alfredo Rodríguez-Antigüedad Sara Eichau Guillermo Izquierdo Carmen Durán Jordi Río Miguel Ángel Hernández Carmen Calles José M. Prieto-González José Ramón Ara Dionisio F. Uría Lucienne Costa-Frossard Antonio García-Merino Celia Oreja-Guevara |
| author_facet | José E. Meca-Lallana Bonaventura Casanova Alfredo Rodríguez-Antigüedad Sara Eichau Guillermo Izquierdo Carmen Durán Jordi Río Miguel Ángel Hernández Carmen Calles José M. Prieto-González José Ramón Ara Dionisio F. Uría Lucienne Costa-Frossard Antonio García-Merino Celia Oreja-Guevara |
| author_sort | José E. Meca-Lallana |
| collection | DOAJ |
| description | BackgroundEarly identification of the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) can be challenging for clinicians, as diagnostic criteria for SPMS are primarily based on physical disability and a holistic interpretation.ObjectiveTo establish a consensus on patient monitoring to identify promptly disease progression and the most useful clinical and paraclinical variables for early identification of disease progression in MS.MethodsA RAND/UCLA Appropriateness Method was used to establish the level of agreement among a panel of 15 medical experts in MS. Eighty-three items were circulated to the experts for confidential rating of the grade of agreement and recommendation. Consensus was defined when ≥66% agreement or disagreement was achieved.ResultsConsensus was reached in 72 out of 83 items (86.7%). The items addressed frequency of follow-up visits, definition of progression, identification of clinical, cognitive, and radiological assessments as variables of suspected or confirmed SPMS diagnosis, the need for more accurate assessment tools, and the use of promising molecular and imaging biomarkers to predict disease progression and/or diagnose SPMS.ConclusionConsensus achieved on these topics could guide neurologists to identify earlier disease progression and to plan targeted clinical and therapeutic interventions during the earliest stages of SPMS. |
| first_indexed | 2024-04-13T10:19:55Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T10:19:55Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-aa9c9b31ac3d4967b3581b1660d1bab52022-12-22T02:50:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-07-011310.3389/fneur.2022.931014931014Consensus on early detection of disease progression in patients with multiple sclerosisJosé E. Meca-Lallana0Bonaventura Casanova1Alfredo Rodríguez-Antigüedad2Sara Eichau3Guillermo Izquierdo4Carmen Durán5Jordi Río6Miguel Ángel Hernández7Carmen Calles8José M. Prieto-González9José Ramón Ara10Dionisio F. Uría11Lucienne Costa-Frossard12Antonio García-Merino13Celia Oreja-Guevara14CSUR Multiple Sclerosis and Clinical Neuroimmunology Unit, Neurology Department, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Murcia, SpainDepartment of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, SpainDepartment of Neurology, Hospital Universitario Cruces, Barakaldo, SpainDepartment of Neurology, Hospital Universitario Virgen Macarena, Sevilla, SpainFundación DINAC, Sevilla, SpainDepartment of Neurology, Hospital Universitario de Badajoz, Badajoz, SpainCEMCAT, Hospital Universitario Vall d'Hebrón, Barcelona, SpainDepartment of Neurology, Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, SpainDepartment of Neurology, Hospital Universitario Son Espases, Palma de Mallorca, Spain0Department of Neurology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain1Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain2Department of Neurology, Hospital Universitario de Cabueñes, Gijón, Spain3Department of Neurology, Hospital Universitario Ramón y Cajal, Madrid, Spain4Department of Neurology, Hospital Universitario Puerta de Hierro, Madrid, Spain5Department of Neurology, Hospital Universitario Clínico San Carlos, Madrid, SpainBackgroundEarly identification of the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) can be challenging for clinicians, as diagnostic criteria for SPMS are primarily based on physical disability and a holistic interpretation.ObjectiveTo establish a consensus on patient monitoring to identify promptly disease progression and the most useful clinical and paraclinical variables for early identification of disease progression in MS.MethodsA RAND/UCLA Appropriateness Method was used to establish the level of agreement among a panel of 15 medical experts in MS. Eighty-three items were circulated to the experts for confidential rating of the grade of agreement and recommendation. Consensus was defined when ≥66% agreement or disagreement was achieved.ResultsConsensus was reached in 72 out of 83 items (86.7%). The items addressed frequency of follow-up visits, definition of progression, identification of clinical, cognitive, and radiological assessments as variables of suspected or confirmed SPMS diagnosis, the need for more accurate assessment tools, and the use of promising molecular and imaging biomarkers to predict disease progression and/or diagnose SPMS.ConclusionConsensus achieved on these topics could guide neurologists to identify earlier disease progression and to plan targeted clinical and therapeutic interventions during the earliest stages of SPMS.https://www.frontiersin.org/articles/10.3389/fneur.2022.931014/fullmultiple sclerosisearly detectionsecondary progressive multiple sclerosisconsensusdisease progression |
| spellingShingle | José E. Meca-Lallana Bonaventura Casanova Alfredo Rodríguez-Antigüedad Sara Eichau Guillermo Izquierdo Carmen Durán Jordi Río Miguel Ángel Hernández Carmen Calles José M. Prieto-González José Ramón Ara Dionisio F. Uría Lucienne Costa-Frossard Antonio García-Merino Celia Oreja-Guevara Consensus on early detection of disease progression in patients with multiple sclerosis Frontiers in Neurology multiple sclerosis early detection secondary progressive multiple sclerosis consensus disease progression |
| title | Consensus on early detection of disease progression in patients with multiple sclerosis |
| title_full | Consensus on early detection of disease progression in patients with multiple sclerosis |
| title_fullStr | Consensus on early detection of disease progression in patients with multiple sclerosis |
| title_full_unstemmed | Consensus on early detection of disease progression in patients with multiple sclerosis |
| title_short | Consensus on early detection of disease progression in patients with multiple sclerosis |
| title_sort | consensus on early detection of disease progression in patients with multiple sclerosis |
| topic | multiple sclerosis early detection secondary progressive multiple sclerosis consensus disease progression |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.931014/full |
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