Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function
The process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environm...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/23/13095 |
| _version_ | 1797507728607805440 |
|---|---|
| author | Francisco Guillen-Chable Andrea Bayona Luis Carlos Rodríguez-Zapata Enrique Castano |
| author_facet | Francisco Guillen-Chable Andrea Bayona Luis Carlos Rodríguez-Zapata Enrique Castano |
| author_sort | Francisco Guillen-Chable |
| collection | DOAJ |
| description | The process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environment facilitating enzymatic reactions at higher concentrations in particular regions of the cell. In this review, we discuss the nucleolus as an example of the establishment, dynamics, and maintenance of a membraneless organelle with a high level of organization. |
| first_indexed | 2024-03-10T04:52:33Z |
| format | Article |
| id | doaj.art-aa9edc72609e46e5ad80882c0f8e39e0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:33Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-aa9edc72609e46e5ad80882c0f8e39e02023-11-23T02:33:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122231309510.3390/ijms222313095Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and FunctionFrancisco Guillen-Chable0Andrea Bayona1Luis Carlos Rodríguez-Zapata2Enrique Castano3Biochemistry and Molecular Plant Biology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, MexicoBiochemistry and Molecular Plant Biology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, MexicoBiotechnology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, MexicoBiochemistry and Molecular Plant Biology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, MexicoThe process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environment facilitating enzymatic reactions at higher concentrations in particular regions of the cell. In this review, we discuss the nucleolus as an example of the establishment, dynamics, and maintenance of a membraneless organelle with a high level of organization.https://www.mdpi.com/1422-0067/22/23/13095nucleolusintrinsically disorderedphase separationfibrillarinphosphoinositides |
| spellingShingle | Francisco Guillen-Chable Andrea Bayona Luis Carlos Rodríguez-Zapata Enrique Castano Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function International Journal of Molecular Sciences nucleolus intrinsically disordered phase separation fibrillarin phosphoinositides |
| title | Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function |
| title_full | Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function |
| title_fullStr | Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function |
| title_full_unstemmed | Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function |
| title_short | Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function |
| title_sort | phase separation of intrinsically disordered nucleolar proteins relate to localization and function |
| topic | nucleolus intrinsically disordered phase separation fibrillarin phosphoinositides |
| url | https://www.mdpi.com/1422-0067/22/23/13095 |
| work_keys_str_mv | AT franciscoguillenchable phaseseparationofintrinsicallydisorderednucleolarproteinsrelatetolocalizationandfunction AT andreabayona phaseseparationofintrinsicallydisorderednucleolarproteinsrelatetolocalizationandfunction AT luiscarlosrodriguezzapata phaseseparationofintrinsicallydisorderednucleolarproteinsrelatetolocalizationandfunction AT enriquecastano phaseseparationofintrinsicallydisorderednucleolarproteinsrelatetolocalizationandfunction |