Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study
Abstract Background The close relationship between pain and mental health problems is well-known, and psychological intervention can provide an effective alternative to medication-based pain relief. However, previous studies on the connection between pain and psychological problems, the findings thu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-023-01612-2 |
| _version_ | 1797784506457915392 |
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| author | Chongjie Yao Yuchen Zhang Ping Lu Bin Xiao Pingping Sun Jiming Tao Yanbin Cheng Lingjun Kong Dongsheng Xu Min Fang |
| author_facet | Chongjie Yao Yuchen Zhang Ping Lu Bin Xiao Pingping Sun Jiming Tao Yanbin Cheng Lingjun Kong Dongsheng Xu Min Fang |
| author_sort | Chongjie Yao |
| collection | DOAJ |
| description | Abstract Background The close relationship between pain and mental health problems is well-known, and psychological intervention can provide an effective alternative to medication-based pain relief. However, previous studies on the connection between pain and psychological problems, the findings thus far have been inconclusive, limiting the potential for translating psychological interventions into clinical practice. To complement the gap, this study utilized genetic data and Mendelian randomization (MR) to examine the potential relationship between pain in different parts and common mental disorders. Methods Based on the instrumental variables selected from the Genome-wide association study summary statistics of localized pain and mental disorders, we conducted bidirectional two-sample MR analyses to infer bidirectional causal associations between pain and mental disorders. The inverse-variance weighted MR method and MR-Egger were used as the primary statistical method according to the horizontal pleiotropy and heterogeneity level. We reported the odds ratio to infer the causal effect between pain and mental disorders. F statistic was calculated to measure the statistical efficacy of the analyses. Results Insomnia is causally related to the genetic susceptibility of multisite pain including head (OR = 1.09, 95% CI: 1.06–1.12), neck/shoulder (OR = 1.12, 95% CI: 1.07–1.16), back (OR = 1.12, 95% CI: 1.07–1.18) and hip (OR = 1.08, 95% CI: 1.05–1.10). Reversely, headache (OR = 1.14, 95% CI: 1.05–1.24), neck/shoulder pain (OR = 1.95, 95% CI: 1.03–3.68), back pain (OR = 1.40, 95% CI: 1.22–1.60), and hip pain (OR = 2.29, 95% CI: 1.18–4.45) promote the genetic liability of insomnia. Depression is strongly associated with the predisposition of multisite pain including headache (OR = 1.28, 95% CI: 1.08–1.52), neck/shoulder pain (OR = 1.32, 95% CI: 1.16–1.50), back pain (OR = 1.35, 95% CI: 1.10–1.66) and stomach/abdominal pain (OR = 1.14, 95% CI: 1.05–1.25), while headache (OR = 1.06, 95% CI: 1.03–1.08), neck/shoulder (OR = 1.09, 95% CI: 1.01–1.17), back (OR = 1.08, 95% CI: 1.03–1.14), and stomach/abdominal pain (OR = 1.19, 95% CI: 1.11–1.26) are predisposing factors for depression. Additionally, insomnia is associated with the predisposition of facial, stomach/abdominal, and knee pain, anxiety was associated with the predisposition of neck/shoulder and back pain, while the susceptibilities of hip and facial pain are influenced by depression, but these associations were unidirectional. Conclusions Our results enhance the understanding of the complex interplay between pain and mental health and highlight the importance of a holistic approach to pain management that addresses both physical and psychological factors. |
| first_indexed | 2024-03-13T00:40:52Z |
| format | Article |
| id | doaj.art-aa9f317637f1462881bccc8c96107d11 |
| institution | Directory Open Access Journal |
| issn | 1129-2377 |
| language | English |
| last_indexed | 2024-03-13T00:40:52Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-aa9f317637f1462881bccc8c96107d112023-07-09T11:19:48ZengBMCThe Journal of Headache and Pain1129-23772023-07-0124111110.1186/s10194-023-01612-2Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization studyChongjie Yao0Yuchen Zhang1Ping Lu2Bin Xiao3Pingping Sun4Jiming Tao5Yanbin Cheng6Lingjun Kong7Dongsheng Xu8Min Fang9Shuguang Hospital, Shanghai University of Traditional Chinese MedicineSchool of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese MedicineSchool of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese MedicineSchool of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese MedicineSchool of Rehabilitation Science, Shanghai University of Traditional Chinese MedicineShuguang Hospital, Shanghai University of Traditional Chinese MedicineYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineShuguang Hospital, Shanghai University of Traditional Chinese MedicineShuguang Hospital, Shanghai University of Traditional Chinese MedicineShuguang Hospital, Shanghai University of Traditional Chinese MedicineAbstract Background The close relationship between pain and mental health problems is well-known, and psychological intervention can provide an effective alternative to medication-based pain relief. However, previous studies on the connection between pain and psychological problems, the findings thus far have been inconclusive, limiting the potential for translating psychological interventions into clinical practice. To complement the gap, this study utilized genetic data and Mendelian randomization (MR) to examine the potential relationship between pain in different parts and common mental disorders. Methods Based on the instrumental variables selected from the Genome-wide association study summary statistics of localized pain and mental disorders, we conducted bidirectional two-sample MR analyses to infer bidirectional causal associations between pain and mental disorders. The inverse-variance weighted MR method and MR-Egger were used as the primary statistical method according to the horizontal pleiotropy and heterogeneity level. We reported the odds ratio to infer the causal effect between pain and mental disorders. F statistic was calculated to measure the statistical efficacy of the analyses. Results Insomnia is causally related to the genetic susceptibility of multisite pain including head (OR = 1.09, 95% CI: 1.06–1.12), neck/shoulder (OR = 1.12, 95% CI: 1.07–1.16), back (OR = 1.12, 95% CI: 1.07–1.18) and hip (OR = 1.08, 95% CI: 1.05–1.10). Reversely, headache (OR = 1.14, 95% CI: 1.05–1.24), neck/shoulder pain (OR = 1.95, 95% CI: 1.03–3.68), back pain (OR = 1.40, 95% CI: 1.22–1.60), and hip pain (OR = 2.29, 95% CI: 1.18–4.45) promote the genetic liability of insomnia. Depression is strongly associated with the predisposition of multisite pain including headache (OR = 1.28, 95% CI: 1.08–1.52), neck/shoulder pain (OR = 1.32, 95% CI: 1.16–1.50), back pain (OR = 1.35, 95% CI: 1.10–1.66) and stomach/abdominal pain (OR = 1.14, 95% CI: 1.05–1.25), while headache (OR = 1.06, 95% CI: 1.03–1.08), neck/shoulder (OR = 1.09, 95% CI: 1.01–1.17), back (OR = 1.08, 95% CI: 1.03–1.14), and stomach/abdominal pain (OR = 1.19, 95% CI: 1.11–1.26) are predisposing factors for depression. Additionally, insomnia is associated with the predisposition of facial, stomach/abdominal, and knee pain, anxiety was associated with the predisposition of neck/shoulder and back pain, while the susceptibilities of hip and facial pain are influenced by depression, but these associations were unidirectional. Conclusions Our results enhance the understanding of the complex interplay between pain and mental health and highlight the importance of a holistic approach to pain management that addresses both physical and psychological factors.https://doi.org/10.1186/s10194-023-01612-2PainMental disorderPsychologyBidirectional relationshipMendelian randomization |
| spellingShingle | Chongjie Yao Yuchen Zhang Ping Lu Bin Xiao Pingping Sun Jiming Tao Yanbin Cheng Lingjun Kong Dongsheng Xu Min Fang Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study The Journal of Headache and Pain Pain Mental disorder Psychology Bidirectional relationship Mendelian randomization |
| title | Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study |
| title_full | Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study |
| title_fullStr | Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study |
| title_full_unstemmed | Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study |
| title_short | Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study |
| title_sort | exploring the bidirectional relationship between pain and mental disorders a comprehensive mendelian randomization study |
| topic | Pain Mental disorder Psychology Bidirectional relationship Mendelian randomization |
| url | https://doi.org/10.1186/s10194-023-01612-2 |
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