Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease
Abstract Objectives To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data of 57 COPD patients were randomized into the control (n = 29, conventional inhalation therapy) or intervent...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01319-9 |
| _version_ | 1797453494087581696 |
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| author | Tao Wang Peng Fu Fa Long Shengming Liu Siyu Hu Qiongping Wang Zhihui Huang Liang Long Wenting Huang Fengbo Hu Jingfan Gan Hongbo Dong Guomei Yan |
| author_facet | Tao Wang Peng Fu Fa Long Shengming Liu Siyu Hu Qiongping Wang Zhihui Huang Liang Long Wenting Huang Fengbo Hu Jingfan Gan Hongbo Dong Guomei Yan |
| author_sort | Tao Wang |
| collection | DOAJ |
| description | Abstract Objectives To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data of 57 COPD patients were randomized into the control (n = 29, conventional inhalation therapy) or intervention group (n = 28, conventional inhalation therapy plus BT). Primary outcomes were differences in clinical symptom changes, pulmonary function-related indicators, modified Medical Research Council (mMRC), 6-min walk test (6MWT), COPD assessment test (CAT) score and acute exacerbation incidence from baseline to an average of 3 and 12 months. Safety was assessed by adverse events. Results FEV1, FEV1(%, predicted) and FVC in both groups improved to varying degrees post-treatment compared with those pre-treatment (P < 0.05). The Intervention group showed greater improving amplitudes of FEV1 (Ftime × between groups = 21.713, P < 0.001) and FEV1(%, predicted) (Ftime × between groups = 31.216, P < 0.001) than the control group, and there was no significant difference in FVC variation trend (Ftime × between groups = 1.705, P = 0.193). mMRC, 6MWT and CAT scores of both groups post-treatment improved to varying degrees (Ps < 0.05), but the improving amplitudes of mMRC (Ftime × between groups = 3.947, P = 0.025), 6MWT (Ftime × between groups = 16.988, P < 0.001) and CAT score (Ftime × between groups = 16.741, P < 0.001) in the intervention group were greater than the control group. According to risk assessment of COPD acute exacerbation, the proportion of high-risk COPD patients with acute exacerbation in the control and intervention groups at 1 year post-treatment (100% vs 65%, 100% vs 28.6%), inpatient proportion (100% vs 62.1%; 100% vs 28.6%), COPD acute exacerbations [3.0 (2.50, 5.0) vs 1.0 (1.0, 2.50); 3.0(3.0, 4.0) vs 0 (0, 1.0)] and hospitalizations [2.0 (2.0, 3.0) vs 1.0 (0, 2.0); 2.0 (2.0, 3.0) vs 0 (0, 1.0)] were significantly lower than those pre-treatment (P < 0.05). Besides, data of the intervention group were significantly lower than the control group at each timepoint after treatment (P < 0.05). Conclusions Combined BT therapy is superior to conventional medical treatment in improving lung function and quality of life of COPD patients, and it also significantly reduces the COPD exacerbation risk without causing serious adverse events. |
| first_indexed | 2024-03-09T15:23:39Z |
| format | Article |
| id | doaj.art-aaa34c1a855947aeac09efca87dbbe1d |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T15:23:39Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-aaa34c1a855947aeac09efca87dbbe1d2023-11-26T12:42:02ZengBMCEuropean Journal of Medical Research2047-783X2023-09-0128111410.1186/s40001-023-01319-9Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary diseaseTao Wang0Peng Fu1Fa Long2Shengming Liu3Siyu Hu4Qiongping Wang5Zhihui Huang6Liang Long7Wenting Huang8Fengbo Hu9Jingfan Gan10Hongbo Dong11Guomei Yan12University of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Jinan UniversityUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalUniversity of Chinese Academy of Sciences Shenzhen HospitalAbstract Objectives To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data of 57 COPD patients were randomized into the control (n = 29, conventional inhalation therapy) or intervention group (n = 28, conventional inhalation therapy plus BT). Primary outcomes were differences in clinical symptom changes, pulmonary function-related indicators, modified Medical Research Council (mMRC), 6-min walk test (6MWT), COPD assessment test (CAT) score and acute exacerbation incidence from baseline to an average of 3 and 12 months. Safety was assessed by adverse events. Results FEV1, FEV1(%, predicted) and FVC in both groups improved to varying degrees post-treatment compared with those pre-treatment (P < 0.05). The Intervention group showed greater improving amplitudes of FEV1 (Ftime × between groups = 21.713, P < 0.001) and FEV1(%, predicted) (Ftime × between groups = 31.216, P < 0.001) than the control group, and there was no significant difference in FVC variation trend (Ftime × between groups = 1.705, P = 0.193). mMRC, 6MWT and CAT scores of both groups post-treatment improved to varying degrees (Ps < 0.05), but the improving amplitudes of mMRC (Ftime × between groups = 3.947, P = 0.025), 6MWT (Ftime × between groups = 16.988, P < 0.001) and CAT score (Ftime × between groups = 16.741, P < 0.001) in the intervention group were greater than the control group. According to risk assessment of COPD acute exacerbation, the proportion of high-risk COPD patients with acute exacerbation in the control and intervention groups at 1 year post-treatment (100% vs 65%, 100% vs 28.6%), inpatient proportion (100% vs 62.1%; 100% vs 28.6%), COPD acute exacerbations [3.0 (2.50, 5.0) vs 1.0 (1.0, 2.50); 3.0(3.0, 4.0) vs 0 (0, 1.0)] and hospitalizations [2.0 (2.0, 3.0) vs 1.0 (0, 2.0); 2.0 (2.0, 3.0) vs 0 (0, 1.0)] were significantly lower than those pre-treatment (P < 0.05). Besides, data of the intervention group were significantly lower than the control group at each timepoint after treatment (P < 0.05). Conclusions Combined BT therapy is superior to conventional medical treatment in improving lung function and quality of life of COPD patients, and it also significantly reduces the COPD exacerbation risk without causing serious adverse events.https://doi.org/10.1186/s40001-023-01319-9COPDBronchial thermoplastyEffectivenessSafety |
| spellingShingle | Tao Wang Peng Fu Fa Long Shengming Liu Siyu Hu Qiongping Wang Zhihui Huang Liang Long Wenting Huang Fengbo Hu Jingfan Gan Hongbo Dong Guomei Yan Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease European Journal of Medical Research COPD Bronchial thermoplasty Effectiveness Safety |
| title | Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease |
| title_full | Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease |
| title_fullStr | Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease |
| title_full_unstemmed | Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease |
| title_short | Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease |
| title_sort | research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease |
| topic | COPD Bronchial thermoplasty Effectiveness Safety |
| url | https://doi.org/10.1186/s40001-023-01319-9 |
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