A Glimpse of necroptosis and diseases
Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222013142 |
| _version_ | 1811180048664756224 |
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| author | Ming Yang Wei Chen Liyu He Di Liu Li Zhao Xi Wang |
| author_facet | Ming Yang Wei Chen Liyu He Di Liu Li Zhao Xi Wang |
| author_sort | Ming Yang |
| collection | DOAJ |
| description | Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases. In this study, we reviewed the molecular mechanism underlying necroptosis, and discuss its role in the pathogenesis of various diseases. Finally, we summarize several current inhibitors of necroptosis and discuss the potential of targeting necroptosis as a therapeutic strategy for various diseases. |
| first_indexed | 2024-04-11T06:44:48Z |
| format | Article |
| id | doaj.art-aaa393162bc04c659205ae37f13e1376 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T06:44:48Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-aaa393162bc04c659205ae37f13e13762022-12-22T04:39:23ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-12-01156113925A Glimpse of necroptosis and diseasesMing Yang0Wei Chen1Liyu He2Di Liu3Li Zhao4Xi Wang5Department of Nutrition, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Nutrition, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Corresponding author at: Department of Nutrition, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases. In this study, we reviewed the molecular mechanism underlying necroptosis, and discuss its role in the pathogenesis of various diseases. Finally, we summarize several current inhibitors of necroptosis and discuss the potential of targeting necroptosis as a therapeutic strategy for various diseases.http://www.sciencedirect.com/science/article/pii/S0753332222013142NecroptosisProgrammed cell deathRIPK1MLKLInflammation |
| spellingShingle | Ming Yang Wei Chen Liyu He Di Liu Li Zhao Xi Wang A Glimpse of necroptosis and diseases Biomedicine & Pharmacotherapy Necroptosis Programmed cell death RIPK1 MLKL Inflammation |
| title | A Glimpse of necroptosis and diseases |
| title_full | A Glimpse of necroptosis and diseases |
| title_fullStr | A Glimpse of necroptosis and diseases |
| title_full_unstemmed | A Glimpse of necroptosis and diseases |
| title_short | A Glimpse of necroptosis and diseases |
| title_sort | glimpse of necroptosis and diseases |
| topic | Necroptosis Programmed cell death RIPK1 MLKL Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222013142 |
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