Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials
Abstract This study aims to evaluate the efficacy and safety of multiple or single‐dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications. A systematic review and meta‐analysis was conducted based on randomized controlled trials...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
|
| Series: | Pharmacology Research & Perspectives |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prp2.1123 |
| _version_ | 1797743671549886464 |
|---|---|
| author | Pengxiang Zhou Lu Chen Ente Wang Lanzhi He Shuxia Tian Suodi Zhai |
| author_facet | Pengxiang Zhou Lu Chen Ente Wang Lanzhi He Shuxia Tian Suodi Zhai |
| author_sort | Pengxiang Zhou |
| collection | DOAJ |
| description | Abstract This study aims to evaluate the efficacy and safety of multiple or single‐dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications. A systematic review and meta‐analysis was conducted based on randomized controlled trials (RCTs) comparing IVIB with placebo or other analgesic and antipyretic medications for postoperative pain and fever management. Data were collected from 8 main databases from the inception to June 2022. Risk of bias assessment was performed, and the GRADE methodology was used to assess the certainty of pooled evidence. Primary outcomes included visual analogue scale (VAS) scores within 24 h postoperative and reduction of temperature. Meta‐analyses were conducted to calculate the mean difference (MD) or risk ratios (RR) and 95% CIs. As a result, a total of twenty‐three RCTs with 3716 participants were included. For postoperative pain, with moderate‐to‐low certainty evidence, IVIB was associated with lower postoperative VAS scores than placebo, with MD ranging from −3.53 (95% CI, −4.32 to −2.75) at 0 min to −0.96 (95% CI, −1.35 to −0.57) at 24 h. Compared with intravenous acetaminophen, IVIB demonstrated lower VAS scores (MD, −1.54 at 0 min; −0.36 at 24 h). For fever, IVIB showed satisfactory antipyretic efficiency in a short period of time, but no difference was observed between IVIB and intravenous acetaminophen. IVIB was well‐tolerated for both pain and fever management. In conclusion, moderate‐to‐low certainty evidence supports the use of IVIB for adults with postoperative pain and fever who are unable to take oral medications. |
| first_indexed | 2024-03-12T14:58:46Z |
| format | Article |
| id | doaj.art-aaa403d79dae4cb2b944da21ce1b977a |
| institution | Directory Open Access Journal |
| issn | 2052-1707 |
| language | English |
| last_indexed | 2024-03-12T14:58:46Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pharmacology Research & Perspectives |
| spelling | doaj.art-aaa403d79dae4cb2b944da21ce1b977a2023-08-14T10:06:44ZengWileyPharmacology Research & Perspectives2052-17072023-08-01114n/an/a10.1002/prp2.1123Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trialsPengxiang Zhou0Lu Chen1Ente Wang2Lanzhi He3Shuxia Tian4Suodi Zhai5Department of Pharmacy Peking University Third Hospital Beijing ChinaDepartment of Pharmacy Peking University Third Hospital Beijing ChinaDepartment of Pharmacy, Beijing Tongren Hospital Capital Medical University Beijing ChinaDepartment of Pharmacy Peking University Third Hospital Beijing ChinaDepartment of Pharmacy Peking University Third Hospital Beijing ChinaDepartment of Pharmacy Peking University Third Hospital Beijing ChinaAbstract This study aims to evaluate the efficacy and safety of multiple or single‐dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications. A systematic review and meta‐analysis was conducted based on randomized controlled trials (RCTs) comparing IVIB with placebo or other analgesic and antipyretic medications for postoperative pain and fever management. Data were collected from 8 main databases from the inception to June 2022. Risk of bias assessment was performed, and the GRADE methodology was used to assess the certainty of pooled evidence. Primary outcomes included visual analogue scale (VAS) scores within 24 h postoperative and reduction of temperature. Meta‐analyses were conducted to calculate the mean difference (MD) or risk ratios (RR) and 95% CIs. As a result, a total of twenty‐three RCTs with 3716 participants were included. For postoperative pain, with moderate‐to‐low certainty evidence, IVIB was associated with lower postoperative VAS scores than placebo, with MD ranging from −3.53 (95% CI, −4.32 to −2.75) at 0 min to −0.96 (95% CI, −1.35 to −0.57) at 24 h. Compared with intravenous acetaminophen, IVIB demonstrated lower VAS scores (MD, −1.54 at 0 min; −0.36 at 24 h). For fever, IVIB showed satisfactory antipyretic efficiency in a short period of time, but no difference was observed between IVIB and intravenous acetaminophen. IVIB was well‐tolerated for both pain and fever management. In conclusion, moderate‐to‐low certainty evidence supports the use of IVIB for adults with postoperative pain and fever who are unable to take oral medications.https://doi.org/10.1002/prp2.1123feverintravenous ibuprofenmeta‐analysispainsystematic review |
| spellingShingle | Pengxiang Zhou Lu Chen Ente Wang Lanzhi He Shuxia Tian Suodi Zhai Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials Pharmacology Research & Perspectives fever intravenous ibuprofen meta‐analysis pain systematic review |
| title | Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials |
| title_full | Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials |
| title_fullStr | Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials |
| title_full_unstemmed | Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials |
| title_short | Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials |
| title_sort | intravenous ibuprofen in postoperative pain and fever management in adults a systematic review and meta analysis of randomized controlled trials |
| topic | fever intravenous ibuprofen meta‐analysis pain systematic review |
| url | https://doi.org/10.1002/prp2.1123 |
| work_keys_str_mv | AT pengxiangzhou intravenousibuprofeninpostoperativepainandfevermanagementinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT luchen intravenousibuprofeninpostoperativepainandfevermanagementinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT entewang intravenousibuprofeninpostoperativepainandfevermanagementinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT lanzhihe intravenousibuprofeninpostoperativepainandfevermanagementinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT shuxiatian intravenousibuprofeninpostoperativepainandfevermanagementinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT suodizhai intravenousibuprofeninpostoperativepainandfevermanagementinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |