Age differences in brain signal variability are robust to multiple vascular controls
Abstract A host of studies support that younger, better performing adults express greater moment-to-moment blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in various cortical regions, supporting an emerging view that the aging brain may undergo a generalized reduction in dynamic rang...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-09752-7 |
| _version_ | 1819127266942124032 |
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| author | Douglas D. Garrett Ulman Lindenberger Richard D. Hoge Claudine J. Gauthier |
| author_facet | Douglas D. Garrett Ulman Lindenberger Richard D. Hoge Claudine J. Gauthier |
| author_sort | Douglas D. Garrett |
| collection | DOAJ |
| description | Abstract A host of studies support that younger, better performing adults express greater moment-to-moment blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in various cortical regions, supporting an emerging view that the aging brain may undergo a generalized reduction in dynamic range. However, the exact physiological nature of age differences in SDBOLD remains understudied. In a sample of 29 younger and 45 older adults, we examined the contribution of vascular factors to age group differences in fixation-based SDBOLD using (1) a dual-echo BOLD/pseudo-continuous arterial spin labeling (pCASL) sequence, and (2) hypercapnia via a computer-controlled gas delivery system. We tested the hypothesis that, although SDBOLD may relate to individual differences in absolute cerebral blood flow (CBF), BOLD cerebrovascular reactivity (CVR), or maximum BOLD signal change (M), robust age differences in SDBOLD would remain after multiple statistical controls for these vascular factors. As expected, our results demonstrated that brain regions in which younger adults expressed higher SDBOLD persisted after comprehensive control of vascular effects. Our findings thus further establish BOLD signal variability as an important marker of the aging brain. |
| first_indexed | 2024-12-22T08:09:12Z |
| format | Article |
| id | doaj.art-aaa6ca9b13cb4532971d70ceced52f74 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-22T08:09:12Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-aaa6ca9b13cb4532971d70ceced52f742022-12-21T18:33:04ZengNature PortfolioScientific Reports2045-23222017-08-017111310.1038/s41598-017-09752-7Age differences in brain signal variability are robust to multiple vascular controlsDouglas D. Garrett0Ulman Lindenberger1Richard D. Hoge2Claudine J. Gauthier3Max Planck UCL Centre for Computational Psychiatry and Ageing ResearchMax Planck UCL Centre for Computational Psychiatry and Ageing ResearchDepartment of Neurology and Neurosurgery, McGill UniversityDepartment of Physics, Concordia UniversityAbstract A host of studies support that younger, better performing adults express greater moment-to-moment blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in various cortical regions, supporting an emerging view that the aging brain may undergo a generalized reduction in dynamic range. However, the exact physiological nature of age differences in SDBOLD remains understudied. In a sample of 29 younger and 45 older adults, we examined the contribution of vascular factors to age group differences in fixation-based SDBOLD using (1) a dual-echo BOLD/pseudo-continuous arterial spin labeling (pCASL) sequence, and (2) hypercapnia via a computer-controlled gas delivery system. We tested the hypothesis that, although SDBOLD may relate to individual differences in absolute cerebral blood flow (CBF), BOLD cerebrovascular reactivity (CVR), or maximum BOLD signal change (M), robust age differences in SDBOLD would remain after multiple statistical controls for these vascular factors. As expected, our results demonstrated that brain regions in which younger adults expressed higher SDBOLD persisted after comprehensive control of vascular effects. Our findings thus further establish BOLD signal variability as an important marker of the aging brain.https://doi.org/10.1038/s41598-017-09752-7 |
| spellingShingle | Douglas D. Garrett Ulman Lindenberger Richard D. Hoge Claudine J. Gauthier Age differences in brain signal variability are robust to multiple vascular controls Scientific Reports |
| title | Age differences in brain signal variability are robust to multiple vascular controls |
| title_full | Age differences in brain signal variability are robust to multiple vascular controls |
| title_fullStr | Age differences in brain signal variability are robust to multiple vascular controls |
| title_full_unstemmed | Age differences in brain signal variability are robust to multiple vascular controls |
| title_short | Age differences in brain signal variability are robust to multiple vascular controls |
| title_sort | age differences in brain signal variability are robust to multiple vascular controls |
| url | https://doi.org/10.1038/s41598-017-09752-7 |
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